Inhibition of Recombinant Human Acetylcholinesterase Activity by Antipsychotics.

08:00 EDT 8th May 2019 | BioPortfolio

Summary of "Inhibition of Recombinant Human Acetylcholinesterase Activity by Antipsychotics."

Extrapyramidal symptoms (EPS) are representative side effects of antipsychotics, caused by their inhibitory action on dopaminergic nerves in nigrostriatal pathways. EPS could be also caused by direct augmentation of cholinergic effects, for example, by acetylcholinesterase (AChE) inhibition. We investigated the potential inhibitory effects of 26 clinically available antipsychotics on the activity of recombinant human AChE (rhAChE) to predict the role of antipsychotic-induced AChE inhibition in EPS onset.


Journal Details

This article was published in the following journal.

Name: Pharmacology
ISSN: 1423-0313
Pages: 43-50


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