Topics

Selective efficacy of Sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains Sac/val and carotid fibrosis.

08:00 EDT 11th May 2019 | BioPortfolio

Summary of "Selective efficacy of Sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains Sac/val and carotid fibrosis."

Sacubitril/valsartan (Sac/val) is more effective than valsartan (Val) in reducing of blood pressure (BP) and mortality in patients with heart failure. In this study we proposed that Sac/val treatment is advantageous in prevention of pathological vascular remodeling in 129X1/SvJ (129X1), but not C57BL/6J (B6) inbred mouse strain.

Affiliation

Journal Details

This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381
Pages:

Links

DeepDyve research library

PubMed Articles [22332 Associated PubMed Articles listed on BioPortfolio]

Sex Influence on the Efficacy and Safety of Sacubitril/Valsartan.

Women are underrepresented in sacubitril/valsartan (SV) clinical trials. The aim of this study was to assess sex-specific differences in efficacy, tolerability, and safety of SV in real-world heart fa...

Recovery of left ventricular dysfunction after sacubitril/valsartan: predictors and management.

Literature describing recovery of left ventricular (LV) function post sacubitril/valsartan treatment and the optimal management of heart failure (HF) patients receiving sacubitril/valsartan remain spa...

Renal effects of Sacubitril/Valsartan in heart failure with reduced ejection fraction: a real life 1-year follow-up study.

Real-life data confirming the favourable renal outcome in patients with heart failure (HF) treated with Sacubitril/Valsartan, previously found in several trials (RCTs), are still scant. We evaluated t...

Interaction Between Sacubitril and Valsartan in Preventing Heart Failure Induced by Aortic Valve Insufficiency in Rats.

Synergistic interactions between neprilysin inhibition (NEPi) with sacubitril and angiotensin receptor type1 blockade (ARB) with valsartan have been implicated in improvement of left ventricular (LV) ...

Evaluation of Patients with Heart Failure To Determine Eligibility for Treatment with Sacubitril/Valsartan: Insights from a Veterans Administration Healthcare System.

Despite evidence that supports the use of sacubitril/valsartan-the first angiotensin II receptor blocker-neprilysin inhibitor-for mortality reduction in patients with heart failure (HF), it remains un...

Clinical Trials [11058 Associated Clinical Trials listed on BioPortfolio]

The Effects of Sacubitril/Valsartan on the Heart Functions

Background: Sacubitril/valsartan, has been found to be more beneficial than enalapril for reducing the incidences of sudden cardiac death, death from worsening heart failure (HF), and ...

Pharmacodynamic Effects of Sacubitril/Valsartan on Natriuretic Peptides, Angiotensin and Neprilysin

The study measure multiple neurohormones in patients with heart failure being treated with Sacubitril/Valsartan in increasing doses over an 8 week period.

The Effects of Sacubitril/Valsartan on Cardiac Oxygen Consumption and Efficiency of Cardiac Work in Heart Failure Patients

The study will assess the effects of 6 weeks of stable sacubitril/valsartan therapy, as compared with valsartan therapy, on cardiac oxygen consumption and the efficiency of cardiac work in...

randOmized stUdy Using acceleromeTry to Compare Sacubitril/valsarTan and Enalapril in Patients With Heart Failure

The purpose of this randomized, actively controlled, double-blind study is to demonstrate the superiority of sacubitril/valsartan over enalapril in increasing non-sedentary physical activi...

Sacubitril/Valsartan in Left Ventricular Assist Device Recipients

The primary objective of this study is to assess the safety and tolerability of sacubitril/valsartan compared with enalapril in patients that have been recently implanted with the HM3 (eve...

Medical and Biotech [MESH] Definitions

Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.

A pharmaceutical preparation of amlodipine and valsartan that is used for the treatment of HYPERTENSION.

Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)

Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.

Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.

Quick Search


DeepDyve research library

Relevant Topic

Vascular
Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...


Searches Linking to this Article