Selective efficacy of Sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains Sac/val and carotid fibrosis.

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Summary of "Selective efficacy of Sacubitril/valsartan on carotid fibrosis in response to injury in two inbred mouse strains Sac/val and carotid fibrosis."

Sacubitril/valsartan (Sac/val) is more effective than valsartan (Val) in reducing of blood pressure (BP) and mortality in patients with heart failure. In this study we proposed that Sac/val treatment is advantageous in prevention of pathological vascular remodeling in 129X1/SvJ (129X1), but not C57BL/6J (B6) inbred mouse strain.


Journal Details

This article was published in the following journal.

Name: British journal of pharmacology
ISSN: 1476-5381


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Medical and Biotech [MESH] Definitions

Possesses an unusual and selective cytotoxicity for VASCULAR SMOOTH MUSCLE cells in dogs and rats. Useful for experiments dealing with arterial injury, myocardial fibrosis or cardiac decompensation.

A pharmaceutical preparation of amlodipine and valsartan that is used for the treatment of HYPERTENSION.

Damages to the CAROTID ARTERIES caused either by blunt force or penetrating trauma, such as CRANIOCEREBRAL TRAUMA; THORACIC INJURIES; and NECK INJURIES. Damaged carotid arteries can lead to CAROTID ARTERY THROMBOSIS; CAROTID-CAVERNOUS SINUS FISTULA; pseudoaneurysm formation; and INTERNAL CAROTID ARTERY DISSECTION. (From Am J Forensic Med Pathol 1997, 18:251; J Trauma 1994, 37:473)

Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.

Blood clot formation in any part of the CAROTID ARTERIES. This may produce CAROTID STENOSIS or occlusion of the vessel, leading to TRANSIENT ISCHEMIC ATTACK; CEREBRAL INFARCTION; or AMAUROSIS FUGAX.

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Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...

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