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Predominance of -regulatory changes in parallel expression divergence of sticklebacks.

08:00 EDT 15th May 2019 | BioPortfolio

Summary of "Predominance of -regulatory changes in parallel expression divergence of sticklebacks."

Regulation of gene expression is thought to play a major role in adaptation but the relative importance of - and - regulatory mechanisms in the early stages of adaptive divergence is unclear. Using RNAseq of threespine stickleback fish gill tissue from four independent marine-freshwater ecotype pairs and their F1 hybrids, we show that -acting (allele-specific) regulation consistently predominates gene expression divergence. Genes showing parallel marine-freshwater expression divergence are found near to adaptive genomic regions, show signatures of natural selection around their transcription start sites and are enriched for regulatory control. For genes with parallel increased expression among freshwater fish, the quantitative degree of and regulation is also highly correlated across populations, suggesting a shared genetic basis. Compared to other forms of regulation, regulation tends to show greater additivity and stability across different genetic and environmental contexts, making it a fertile substrate for the early stages of adaptive evolution.

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Name: eLife
ISSN: 2050-084X
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