Shear-, Sound-, and Light-Sensitive Nanoparticles for Thrombolytic Drug Delivery.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Shear-, Sound-, and Light-Sensitive Nanoparticles for Thrombolytic Drug Delivery."

Thrombotic diseases, as potentially induced by blood clots or vascular embolization, frequently occur with high rates of mortalities worldwide. Current drug thrombolysis, a primary clinical therapy, may increase fatal risk of hemorrhage when thrombolysis agents become systemically distributed. Given current thrombolysis limitations, some novel drug delivery systems based on nanoparticles have been recently exploited to achieve a more controlled release of loaded thrombolytic agents, able to respond to environmental changes, and resulting in a safer thrombolysis. In this review, the authors outline and discuss some prominent examples of early and recent thrombolytic agent delivery systems using controlled release by physical stimuli (shear, sound and light). Shear-sensitive systems are designed to exploit the specific biomechanical feature of thrombosis, that is, the increased blood shear stress. Sound- and light-sensitive systems reflect "remote control" of drug release by responding to external ultrasound or light stimulus. These smart thrombolytic drug delivery systems hold promise for more effective and safer future thrombolytic therapy.


Journal Details

This article was published in the following journal.

Name: Seminars in thrombosis and hemostasis
ISSN: 1098-9064


DeepDyve research library

PubMed Articles [20375 Associated PubMed Articles listed on BioPortfolio]

Development of Novel pH-sensitive Nanoparticles Loaded Hydrogel for Transdermal Drug Delivery.

Difference of pH that exists between the skin surface and blood circulation can be exploited for transdermal delivery of drug molecules by loading drug into pH-sensitive polymer. Eudragit S100 (ES100)...

Cathepsin-sensitive nanoscale drug delivery systems for cancer therapy and other diseases.

Cathepsins are an important category of enzymes that have attracted great attention for the delivery of drugs to improve the therapeutic outcome of a broad range of nanoscale drug delivery systems. Th...

Near infrared light-triggered nanoparticles using singlet oxygen photocleavage for drug delivery systems.

Drug delivery systems (DDSs) have showed a reduced systemic toxicity and enhanced therapeutic efficacy over conventional cancer treatments. However, after reaching the damaged tissue, DDSs should pres...

Preparation and characterization of rod-like chitosan-quinoline nanoparticles as pH-responsive nanocarriers for quercetin delivery.

Novel chitosan-quinoline nanoparticles as anticancer drug nanocarriers were prepared using 2-chloro-3-formylquinoline and 3-formylquinolin-2(1H)-one as non-toxic modifying agents via oil-in-water nano...

Starch nanoparticles in drug delivery: A review.

The uptake and specificity of drugs and the bioavailability of poorly soluble drugs has been improved by means of targeted drug delivery using nanoparticles. Many platforms have been used for nanopart...

Clinical Trials [7542 Associated Clinical Trials listed on BioPortfolio]

Topical Silver Nanoparticles for Microbial Activity

Silver nanoparticles are one of most nanoparticles use nowadays in the research area because it has specific physical and chemical properties, in medical fields silver nanoparticles can in...

Beyond Confounders: Addressing Source of Measurement Variability and Error in Shear Wave Elastography

Chronic liver disease is a major problem in the general population and there is an unmet need to diagnose(and screen) for liver disease with using noninvasive, cost-effective and sensitive...

Topical Application of Silver Nanoparticles and Oral Pathogens in Ill Patients

The purpose of this study is to determine whether oral topic silver nanoparticles are effective to reduce potential pathogen microbial loads in mechanical ventilation patients.

Use of a Shear Reduction Surface in Pre-hospital Transport

Does the use of an anti-shear mattress overlay placed on a pre-hospital transport stretcher reduce shear forces and pressure on the skin, and increase patient comfort as compared to standa...

Myocardial Infarction Triage and Intervention Project (MITI)

To determine the practicality, benefit, and safety of paramedic administration of thrombolytic therapy for acute myocardial infarction. The feasibility of paramedics correctly identifying...

Medical and Biotech [MESH] Definitions

Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.

Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.

The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)

Synthesized magnetic particles under 100 nanometers possessing many biomedical applications including DRUG DELIVERY SYSTEMS and CONTRAST AGENTS. The particles are usually coated with a variety of polymeric compounds.

Diamond nanoparticles that exhibit unique biological, thermal, mechanical, and optoelectronic properties. They have important NANOMEDICINE applications including DRUG DELIVERY SYSTEMS; DIAGNOSTIC IMAGING; protein separation; and BIOSENSING TECHNIQUES.

Quick Search


DeepDyve research library

Relevant Topics

Drug Delivery
<!--LGfEGNT2Lhm-->Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals.  <!--LGfEGNT2Lhm-->Drug delivery technologies are <!--LGfEGNT2Lhm-->patent pr...

Vascular relates to blood vessels (Oxford Medical Dictionary) and can be used to describe the supply of blood, a disease affecting the blood vessels or molecules associated with these structures. For example, <!--LGfEGNT2Lhm-->atherosclerosis ...

Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Searches Linking to this Article