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Non-small cell lung cancer (NSCLC) is demonstrated as one of the most common malignant tumors and accounts for about 25% of cancer-related deaths each year. Extensive bodies of studies have manifested that microRNAs (miRNAs) play pivotal roles in the development of numerous malignant tumors by involving in modulation of cell biological processes. Although miR-4319 has been validated to execute tumor suppressor properties in triple-negative breast cancer, explorations on the function and latent mechanism of miR-4319 participating in NSCLC are still unclear. In this study, we proved that miR-4319 acted as a tumor suppressor in NSCLC progression via restraining cell proliferation and migration as well as boosting apoptosis. Further, miR-4319 bound with LIN28 and negatively regulated the expression of LIN28. Our data unveiled that LIN28 promoted RFX5 mRNA stability and miR-4319 led to the destabilization of RFX5 by targeting LIN28. In addition, RFX5 motivated the transcription of YAP and enhanced expression of YAP abolished the miR-4319 upregulation-mediated suppressive regulation of NSCLC tumorigenesis. In conclusion, miR-4319 dampened YAP expression to mitigate the tumorigenesis of NSCLC through inhibiting LIN28-mediated RFX5 stability, which offered an insight into the molecular mechanism underlying miR-4319 in NSCLC development.
This article was published in the following journal.
Name: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
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Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A cell adhesion molecule that contains extracellular immunoglobulin V and C2 domains. It mediates homophilic and heterophilic cell-cell adhesion independently of calcium, and acts as a tumor suppressor in NON-SMALL-CELL LUNG CANCER (NSCLC) cells. Its interaction with NATURAL KILLER CELLS is important for their cytotoxicity and its expression by MAST CELLS plays a role in their interaction with neurons; it may also function in synapse assembly, nerve growth and differentiation.
A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine kinase. It is used in the treatment of NON-SMALL CELL LUNG CANCER.
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