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Carbon dots (CDs) with both one- and two-photon fluorescence have attracted much attention in the field of bioimaging. In this study, we reported a strategy for the design of peptide-conjugated CDs for cellular nuclear-targeted imaging. The CDs were prepared from amino acid and formic acid via an one-step hydrothermal synthesis method, and then modified with trans-activator of transcription (TAT) peptide for both one- and two- photon nuclear-targeted fluorescence imaging. The CDs derived from tryptophan (Trp) and formic acid showed the highest fluorescence quantum yield of 58.4% with an average size about 1.7 nm in diameter. The maximum excitation and emission wavelengths of the Trp/formic acid CDs were 360 and 442 nm, respectively. The Trp/formic acid CDs were successfully conjugated with TAT peptide through the reaction between the amino group of the peptide and carboxylic group of the CDs. Upon grafting with TAT peptide, the resulted TAT-Trp/formic acid CDs could be used as nuclear-targeted fluorescent probes for both one- and two-photon live cell fluorescence imaging.
This article was published in the following journal.
Name: Colloids and surfaces. B, Biointerfaces
This short review (with 72 refs.) summarizes the state of the art in fluorometric methods for targeted imaging of cancer cells and tumor tissues in order to differentiate between normal cells and ca...
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Nuclear reaction in which the nucleus of a heavy atom such as uranium or plutonium is split into two approximately equal parts by a neutron, charged particle, or photon.
Nanometer sized fragments (the dots) of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They are brighter and more persistent than organic chemical INDICATORS. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY.
Tomography using single-photon emitting RADIONUCLIDES to create images that are captured in times corresponding to various points in the cardiac cycle.
Compounds consisting of a short peptide chain conjugated with an acyl chain.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).