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Thrombomodulin alfa prevents the decrease in platelet aggregation in rat models of disseminated intravascular coagulation.

08:00 EDT 4th May 2019 | BioPortfolio

Summary of "Thrombomodulin alfa prevents the decrease in platelet aggregation in rat models of disseminated intravascular coagulation."

Disseminated intravascular coagulation (DIC), a deadly complication characterized by uncontrolled hypercoagulation, causes a decrease in the platelet count and impairs platelet aggregation. Thrombomodulin (TM) alfa, a recombinant human soluble TM, reduces hypercoagulation in DIC patients. However, the effects of TM alfa on impaired platelet aggregation remain to be determined. In this study, we aim to investigate the effects of TM alfa on platelet aggregation using lipopolysaccharide (LPS)-induced and tissue factor (TF)-induced DIC rat models.

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This article was published in the following journal.

Name: Thrombosis research
ISSN: 1879-2472
Pages: 73-80

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