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This study longitudinally investigates the effect of depressive disorder on psychiatric disorder in middle aged and aged population from the Korean Longitudinal Study of Aging. Data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2016 was assessed using longitudinal data analysis and 7515 research samples were included after excluding those with cognitive decline and missing information at baseline (2006). To analyze the association between depressive disorder on cognitive decline in middle aged and aged population, generalized estimating equation (GEE) model and chi-square test were used. The association between depressive symptom during a week and center for epidemiological studies depression (CESD) on cognitive decline was statistically significant, respectively with the following Odds ratio (OR) predicting decreased MMSE score: OR = 0.89 (p < .0001) for 5-7 days vs. less than a day and B = 0.91 (p < .0001) for depression (8-10) vs. healthy (zero). In terms of cognitive decline, depressive symptom was higher for 5-7 days (OR = 3.79, p < .0001) compared to less than a day. This study shows a statistically significant association between depressive disorder and cognitive decline in a Korean middle aged and aged population. These findings suggest the importance of managing depressive disorder for incident cognitive decline.
This article was published in the following journal.
Name: Archives of gerontology and geriatrics
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An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Unexplained neurologic condition characterized by episodes of atonic seizures, convulsions or staring spells with further cognitive decline.
A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
A dibenzothiazepine and ANTIPSYCHOTIC AGENT that targets the SEROTONIN 5-HT2 RECEPTOR; HISTAMINE H1 RECEPTOR, adrenergic alpha1 and alpha2 receptors, as well as the DOPAMINE D1 RECEPTOR and DOPAMINE D2 RECEPTOR. It is used in the treatment of SCHIZOPHRENIA; BIPOLAR DISORDER and DEPRESSIVE DISORDER.
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