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Bone penetration of Daptomycin in diabetic patients with bacterial foot infections.

08:00 EDT 13th May 2019 | BioPortfolio

Summary of "Bone penetration of Daptomycin in diabetic patients with bacterial foot infections."

Daptomycin has shown clinical efficacy in diabetic foot infections (DFI). However, few data are available about its bone penetration in this particular population. We aimed to determine daptomycin bone concentrations in patients with diabetic foot infection that underwent surgery after multiple daptomycin infusions and determine bone daptomycin inhibitory quotients (IQs) for predominant Gram-positive species involved in DFI.

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This article was published in the following journal.

Name: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
ISSN: 1878-3511
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Medical and Biotech [MESH] Definitions

Common foot problems in persons with DIABETES MELLITUS, caused by any combination of factors such as DIABETIC NEUROPATHIES; PERIPHERAL VASCULAR DISEASES; and INFECTION. With the loss of sensation and poor circulation, injuries and infections often lead to severe foot ulceration, GANGRENE and AMPUTATION.

Peripheral, autonomic, and cranial nerve disorders that are associated with DIABETES MELLITUS. These conditions usually result from diabetic microvascular injury involving small blood vessels that supply nerves (VASA NERVORUM). Relatively common conditions which may be associated with diabetic neuropathy include third nerve palsy (see OCULOMOTOR NERVE DISEASES); MONONEUROPATHY; mononeuropathy multiplex; diabetic amyotrophy; a painful POLYNEUROPATHY; autonomic neuropathy; and thoracoabdominal neuropathy. (From Adams et al., Principles of Neurology, 6th ed, p1325)

Devices used to support or align the foot structure, or to prevent or correct foot deformities.

A course of food intake prescribed for patients, that limits the amount of foods with a high GLYCEMIC INDEX.

Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.

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