Nomogram predicted survival of breast cancer brain metastasis (BCBM): a SEER-based population study.

08:00 EDT 13th May 2019 | BioPortfolio

Summary of "Nomogram predicted survival of breast cancer brain metastasis (BCBM): a SEER-based population study."

The prognosis of breast cancer brain metastasis (BCBM) patients was dismal and the prognoses varied by different prognostic factors. In the present study, we identified and built a robust prognostic model and developed reliable nomograms to estimate the individualized overall survival (OS) and breast cancer-specific survival (BCSS) of breast cancer patients with brain metastasis. A total of 789 newly diagnosed breast cancer brain metastasis (BCBM) patients were identified from the Surveillance Epidemiology and End Results (SEER) database and randomly divided into training (n=554) and testing (n=235) cohorts. The log-rank tests and the Cox proportional hazards model were applied to evaluate the prognostic effects of multiple clinicopathological variables on the survival of training cohorts. Significant prognostic factors were combined to build the nomograms that were evaluated using the index of concordance (C-index) and calibration plots for internal and external validations. Two nomograms shared the common prognostic indicators including age, tumor subtype, chemotherapy, surgery, and number of metastatic sites except the brain and median household income. In the training cohort, the Harrell's C-index for the constructed nomogram to predict OS and BCSS were 0.668 and 0.676, respectively. The calibration plots were consistent between the nomogram-predicted survival probability and actual survival probability. These results were reproducible when nomograms were applied to the testing cohort for external validation. In conclusion, nomograms that predicted 6-month, 1-, and 2-year OS and BCSS for newly diagnosed BCBM patients with satisfactory performance were constructed to help the physicians in evaluating the high risk of mortality in patients.


Journal Details

This article was published in the following journal.

Name: World neurosurgery
ISSN: 1878-8769


DeepDyve research library

PubMed Articles [27650 Associated PubMed Articles listed on BioPortfolio]

Prognostic Value of Brain Metastasis Free Interval in Patients with Breast Cancer Brain Metastases.

In patients with breast cancer brain metastases (BCBM), time between primary tumor diagnosis and appearance of brain metastases varies widely. Despite being a readily available clinical parameter, it ...

Salvage Stereotactic Radiosurgery in Breast Cancer Patients With Multiple Brain Metastases.

The overall survival rates for breast cancer are increasing due to controlled brain disease and improved systemic treatments. This study examined neurological outcomes, tumor control, and survival dat...

Co-expression network analysis of gene expression profiles of HER2 breast cancer-associated brain metastasis.

Brain metastasis occurs in ~30% of patients with breast cancer, and patients with human epidermal growth factor receptor 2 (HER2) breast cancer have a particularly high frequency of brain metastasis. ...

A five-miRNA signature predicts survival in gastric cancer using bioinformatics analysis.

Abnormal expression of miRNAs is critical for gastric cancer progression. Here, we aimed to identify the differential expression of miRNAs in normal and cancerous gastric tissues and build a nomogram ...

Impact of time to local recurrence on the occurrence of metastasis in breast cancer patients treated with neoadjuvant chemotherapy: A random forest survival approach.

We studied the relationship between time to ipsilateral breast tumor recurrence (IBTR) and distant metastasis-free survival (DMFS) in patients with breast cancer treated by neoadjuvant chemotherapy (N...

Clinical Trials [20947 Associated Clinical Trials listed on BioPortfolio]

Verifying the Specificity of a New Method in Predicting Lymph Node Metastasis in Early Gastric Cancer Patients

Early gastric cancer is defined as gastric cancer that only invades mucosal or submucosal layer. The 5-year survival rate of gastric cancer can exceed 90% due to appropriate treatment. The...

Kadcyla In pAtients With bRAin Metastasis

Women with breast cancer often develop metastases in the brain. Currently, treatment of these metastases is difficult and relies on radiotherapy or surgery which often fail. Therefore, dev...

Breast Cancer With Over-expression of erbB2-BRAINSTORM

This retrospective cohort study aims to improve our understanding of the current paradigm for treatment of brain metastases in erbB2+ breast cancer patients in the Asia Pacific region. We ...

Eribulin in Brain Metastases From HER2-negative Breast Cancer

To evaluate the efficacy of eribulin for treatment of HER2-negative breast cancer brain metastases (BCBM)

Bone Response in Metastatic Breast Cancer Involving Bones

Primary Objectives: - To estimate and compare the sensitivity and specificity of computed tomography (CT), plain radiography (XR), and skeletal scintigraphy (SS) with each other f...

Medical and Biotech [MESH] Definitions

Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.

A infiltrating (invasive) breast cancer, relatively uncommon, accounting for only 5%-10% of breast tumors in most series. It is often an area of ill-defined thickening in the breast, in contrast to the dominant lump characteristic of ductal carcinoma. It is typically composed of small cells in a linear arrangement with a tendency to grow around ducts and lobules. There is likelihood of axillary nodal involvement with metastasis to meningeal and serosal surfaces. (DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1205)

Abnormal accumulation of lymph in the arm, shoulder and breast area associated with surgical or radiation breast cancer treatments (e.g., MASTECTOMY).

A deoxycytidine derivative and fluorouracil PRODRUG that is used as an ANTINEOPLASTIC ANTIMETABOLITE in the treatment of COLON CANCER; BREAST CANCER and GASTRIC CANCER.

Carbohydrate antigen elevated in patients with tumors of the breast, ovary, lung, and prostate as well as other disorders. The mucin is expressed normally by most glandular epithelia but shows particularly increased expression in the breast at lactation and in malignancy. It is thus an established serum marker for breast cancer.

Quick Search


DeepDyve research library

Relevant Topics

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Breast Cancer
Track and monitor developments in breast cancer research and commercial development.  Follow the tabs above to read the latest global news, research, clinical trials on breast cancer and follow companies active in the development of breast cancer tr...

Searches Linking to this Article