Treatment of bone and joint infections caused by Enterobacter cloacae with a fluoroquinolone-cotrimoxazole combination.

08:00 EDT 13th May 2019 | BioPortfolio

Summary of "Treatment of bone and joint infections caused by Enterobacter cloacae with a fluoroquinolone-cotrimoxazole combination."

Although the frequency of bone and joint infection caused by Enterobacter spp is increasing, studies regarding the optimal antibiotic therapy are scarce. The objective of the current retrospective study was to assess the clinical outcomes and safety of a fluoroquinolone-cotrimoxazole combination for the treatment of bone and joint infections caused by E. cloacae. Between 2010 and 2017, 30 patients with bone and joint infection caused by E. cloacae were treated with a fluoroquinolone-cotrimoxazole combination for 8 to 12 weeks. The type of infection was infection of an internal fixation device in 26 cases (87%), pseudarthrosis with chronic osteomyelitis in 2 cases (6.6%), and infection of knee and ankle prosthetic devices in 2 cases (6.6%). The cure rate of the fluoroquinolone-cotrimoxazole combination was 80% by intention-to-treat with a mean follow-up of 29.3± 19.1 months. The fluoroquinolone-cotrimoxazole combination for 8 to 12 weeks is effective for the treatment of bone and joint infection caused by E. cloacae.


Journal Details

This article was published in the following journal.

Name: International journal of antimicrobial agents
ISSN: 1872-7913


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A species of gram-negative bacteria in the genus ENTEROBACTER, found in the environment and in foods. It has biochemical characteristics similar to ENTEROBACTER CLOACAE, but is yellow-pigmented.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria that occurs in water, sewage, soil, meat, hospital environments, and on the skin and in the intestinal tract of man and animals as a commensal.

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