Microbial production of cyanophycin: From enzymes to biopolymers.

08:00 EDT 13th May 2019 | BioPortfolio

Summary of "Microbial production of cyanophycin: From enzymes to biopolymers."

Cyanophycin is an attractive biopolymer with chemical and material properties that are suitable for industrial applications in the fields of food, medicine, cosmetics, nutrition, and agriculture. For efficient production of cyanophycin, considerable efforts have been exerted to characterize cyanophycin synthetases (CphAs) and optimize fermentations and downstream processes. In this paper, we review the characteristics of diverse CphAs from cyanobacteria and non-cyanobacteria. Furthermore, strategies for cyanophycin production in microbial strains, including Escherichia coli, Pseudomonas putida, Ralstonia eutropha, Rhizopus oryzae, and Saccharomyces cerevisiae, heterologously expressing different cphA genes are reviewed. Additionally, chemical and material properties of cyanophycin and its derivatives produced through biological or chemical modifications are reviewed in the context of their industrial applications. Finally, future perspectives on microbial production of cyanophycin are provided to improve its cost-effectiveness.


Journal Details

This article was published in the following journal.

Name: Biotechnology advances
ISSN: 1873-1899


DeepDyve research library

PubMed Articles [9957 Associated PubMed Articles listed on BioPortfolio]

De Novo production of benzyl glucosinolate in Escherichia coli.

Microbial production of plant specialised metabolites is challenging as the biosynthetic pathways are often complex and can contain enzymes, which function is not supported in traditional production h...

Antimicrobial, anticancer drug carrying properties of biopolymers-based nanocomposites-A mini review.

Biopolymers are ubiquitous in biomedical and healthcare application. Its nanocomposites have gained the more attention as antimicrobials, drug carrier, sensors, disease diagnosis, tissue engineering, ...

Naturally-derived biopolymers: Potential platforms for enzyme immobilization.

Naturally-derived biopolymers such as alginate, chitosan, cellulose, agarose, guar gum/guaran, agar, carrageenan, gelatin, dextran, xanthan, and pectins, etc. have appealed significant attention over ...

The role and mechanism of microbial 3-ketosteroid Δ-dehydrogenases in steroid breakdown.

3-Ketosteroid Δ-dehydrogenases are FAD-dependent enzymes that catalyze the introduction of a double bond between the C1 and C2 atoms of the A-ring of 3-ketosteroid substrates. These enzymes are found...

Enhancement of cellulase production in Trichoderma reesei RUT-C30 by comparative genomic screening.

Cellulolytic enzymes produced by the filamentous fungus Trichoderma reesei are commonly used in biomass conversion. The high cost of cellulase is still a significant challenge to commercial biofuel pr...

Clinical Trials [3023 Associated Clinical Trials listed on BioPortfolio]

Whole Grain and Fiber Addition Study

The human gut microbiota is the complex community of bacteria that reside within the human gastrointestinal tract. This community plays an important role in supporting normal immune functi...

Effect of Microbial Exposure on Health, Particularly Immune System

The effect of microbial exposure on healthy human subjects will be investigated. Changes in cytokine and IgE and vaccine response will be measured. The hypothesis is that microbial exposur...

Diagnosis of Septicaemia by Detection of Microbial DNA in Blood in Severe Infections

The primary purpose is to improve and quicken the microbial diagnosis in severe infections, since only one third of the cases are documented by blood cultures and adequate anti-infective t...

Pediatric FEcal Microbial Transplantation for Ulcerative Colitis

The objective of this pilot study is to assess the feasibility of fecal microbial transplants for the therapy of pediatric ulcerative colitis. Specifically, the investigators will test the...

Exercise, Hypertension, and Gut Dysbiosis in African Americans

African Americans have the greatest burden of endothelial dysfunction and hypertension. Recently, gut microbial dysbiosis (a term that describes a poorly diverse gut microbial profile and ...

Medical and Biotech [MESH] Definitions

Fatty acid biopolymers that are biosynthesized by microbial polyhydroxyalkanoate synthase enzymes. They are being investigated for use as biodegradable polyesters.

Enumeration by direct count of viable, isolated bacterial, archaeal, or fungal CELLS or SPORES capable of growth on solid CULTURE MEDIA. Each colony (i.e., microbial colony-forming unit) represents the progeny of a single cell in the original inoculum. The method is used routinely by environmental microbiologists for quantifying organisms in AIR; FOOD; and WATER; by clinicians for measuring patients' microbial load; and in antimicrobial drug testing.

Foods and beverages that are prepared by using microorganisms to convert their components into various FERMENTATION end products. Some pickled foods are considered fermented foods as their pickling results from the microbial production of LACTIC ACID.

A frequent complication of drug therapy for microbial infection. It may result from opportunistic colonization following immunosuppression by the primary pathogen and can be influenced by the time interval between infections, microbial physiology, or host resistance. Experimental challenge and in vitro models are sometimes used in virulence and infectivity studies.

Light absorbing proteins and protein prosthetic groups found in certain microorganisms. Some microbial photoreceptors initiate specific chemical reactions which signal a change in the environment, while others generate energy by pumping specific ions across a cellular membrane.

Quick Search


DeepDyve research library

Relevant Topics

Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Searches Linking to this Article