Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na current, contractility, and Ca release in murine hearts.

08:00 EDT 13th May 2019 | BioPortfolio

Summary of "Inhibition of PI3Kinase-α is pro-arrhythmic and associated with enhanced late Na current, contractility, and Ca release in murine hearts."

Phosphoinositide 3-kinase α (PI3Kα) is a proto-oncogene with high activity in the heart. BYL719 (BYL) is a PI3Kα-selective small molecule inhibitor and a prospective drug for advanced solid tumors. We investigated whether acute pharmacological inhibition of PI3Kα has pro-arrhythmic effects.


Journal Details

This article was published in the following journal.

Name: Journal of molecular and cellular cardiology
ISSN: 1095-8584


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