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Dose dependent study of effects of 532 nm CW laser on rat skin: A mechanistic insight.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Dose dependent study of effects of 532 nm CW laser on rat skin: A mechanistic insight."

Visible lasers emitting in green spectral region are being routinely employed in various medical and defence fields viz. treatment of pigmented lesions, tattoo inks, port wine stains, dazzling the target or mob dispersal. Despite their increasing applications, lasers also tend to pose occupational hazards to operators, ancillary personnel, individuals undergoing laser therapies. This study was aimed at investigating the effects of different doses of 532 nm continuous wave laser on rat skin. The present study demonstrated that higher fluences of 532 nm CW laser induces significant tissue damage through induction of TNF α, COX-2, p53, PARP 1, caspase3 which in turn leads to tissue damage and cell death. Furthermore, level of heat shock proteins, pAkt were found up-regulated as a cope up response to laser-induced stress. On the basis of the findings, irradiation with 532 nm CW laser up to 2.5 J/cm was found within the safe exposure limits. Thus, it is probably the first attempt to demonstrate the tissue damage induced by 532 nm CW laser on skin, which may help in choosing safe laser dose for certain skin-based applications and evolving methods to ameliorate laser-inflicted injuries. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Journal of biophotonics
ISSN: 1864-0648
Pages: e201800484

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