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An enantioselective nickel(0)-catalyzed C-H functionalization of indoles and pyrroles without the need for the typical Lewis-basic directing groups is disclosed. The reaction provides access to valuable tetrahydropyridoindoles and tetrahydroindolizines in high yields and enantioselectivities under mild reaction conditions. The process is characterized by a clean endo-cyclization preference to yield the sought-after six-membered ring products. Key for the success of the activation and selectivity in the cyclization was the development of a novel chiral SIPr carbene ligand analogue with very bulky flanking groups.
This article was published in the following journal.
Name: Angewandte Chemie (International ed. in English)
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