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Hepatitis E during pregnancy: maternal and fetal case-fatality rates and adverse outcomes - a systematic review.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Hepatitis E during pregnancy: maternal and fetal case-fatality rates and adverse outcomes - a systematic review."

Hepatitis E virus infection during pregnancy can have severe consequences for mother and child, such as vertical transmission, fulminant hepatic failure, even fetal or maternal mortality. The aim of this systematic review is to describe maternal, fetal and neonatal case-fatality rates as well as the prevalence of adverse outcomes in relation to hepatitis E virus infection during pregnancy. A systematic literature search was performed in Pubmed, Embase, Cochrane and CINAHL. Search terms included; Pregnant, Women, Maternal, Infant, Fetal, Neonatal and Hepatitis E virus. Data were extracted using predefined data collection forms. All studies were quality assessed, either by the Newcastle-Ottawa Scale or by an adapted assessment scale for cross-sectional studies. We found 23 eligible studies, all observational, which were included in this systematic review with a total of 1,338 cases. The median maternal, fetal and neonatal case-fatality rates were 26% (IQR 17%-41%), 33% (IQR 19%-37%) and 8% (IQR 3%-20%), respectively. Adverse outcomes such as fulminant hepatic failure, preterm labor, postpartum hemorrhage, low birth weight and vertical transmission were reported. The two studies that reported the highest prevalence of fulminant hepatic failure also reported the highest case-fatality rates. The median prevalence of fulminant hepatic failure was 45.3%. This systematic review found a high case-fatality rate among pregnant women infected with hepatitis E virus and a high rate of adverse outcomes among these women and their children. The results from this review mainly apply to hospital settings and symptomatic pregnant women from endemic countries. This article is protected by copyright. All rights reserved.

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This article was published in the following journal.

Name: Journal of viral hepatitis
ISSN: 1365-2893
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