Track topics on Twitter Track topics that are important to you
Tumor hypoxia compromises the therapeutic efficiency of photodynamic therapy (PDT) as the local oxygen concentration plays an important role in the generation of cytotoxic singlet oxygen ( O ). Herein, a versatile mesoporous nanoenzyme (NE) derived from metal-organic frameworks (MOFs) is presented for in situ generation of endogenous O to enhance the PDT efficacy under bioimaging guidance. The mesoporous NE is constructed by first coating a manganese-based MOFs with mesoporous silica, followed by a facile annealing process under the ambient atmosphere. After removing the mesoporous silica shell and post-modifying with polydopamine and poly(ethylene glycol) for improving the biocompatibility, the obtained mesoporous NE is loaded with chlorin e6 (Ce6), a commonly used photosensitizer in PDT, with a high loading capacity. Upon the O generation through the catalytic reaction between the catalytic amount NE and the endogenous H O , the hypoxic tumor microenvironment is relieved. Thus, Ce6-loaded NE serves as a H O -activated oxygen supplier to increase the local O concentration for significantly enhanced antitumor PDT efficacy in vitro and in vivo. In addition, the NE also shows T -weighted magnetic resonance imaging ability for its in vivo tracking. This work presents an interesting biomedical use of MOF-derived mesoporous NE as a multifunctional theranostic agent in cancer therapy.
This article was published in the following journal.
Name: Advanced materials (Deerfield Beach, Fla.)
ZnS nanoparticles wrapped in N-doped mesoporous carbon nanosheets are prepared from metal-organic frameworks through a simple co-pyrolysis process. In the composite interface, ZnS nanoparticles are di...
Metal-organic frameworks (MOFs) are an emerging class of porous materials with attractive properties; however, their practical applications are heavily hindered by the fragile nature. We report herein...
This article explains the need for energy-efficient large-scale CO2 capture and briefly mentions the requirements for optimal solid sorbents for this application. It illustrates the potential of ultra...
Fabrication of molybdenum and tungsten oxide, sulfide, phosphide (MoWO/MoWS/MoWP) porous hollow nano-octahedrons from metal-organic frameworks templates as efficient hydrogen evolution reaction electrocatalysts.
A metal-organic frameworks-derived sulfuration and phosphorization method is developed for constructing a hydrogen evolution reaction (HER) electrocatalyst (MoWOSP@C), which is composed of MoWO nanopa...
Mixed-metal metal organic frameworks (MM-MOFs) can be considered those MOFs having two metals anywhere in the structure. The present review summarizes the various strategies reported for preparation o...
Although the metal-ceramic system is still widely used to fabricate crowns and fixed partial dentures and is considered as the standard treatment in dentistry, aesthetic concerns have stim...
This is a multi-center, randomized study to compare blood and urine cobalt, chromium, and titanium ion levels of a metal-on-metal articular bearing coupled with two different head sizes to...
The aim of this study is to demonstrate the non-inferiority of the ceramic-on-metal articulation using large diameter bearings (38mm to 60mm) compared to the metal on metal articulation us...
A clinical Evaluation to determine metal ion release from 4th generation metal-on-metal hip articulating surfaces in cementless total hip arthroplasty.
The objective of the present study is to contribute to establishing in vivo phenotyping procedures for organic anionic transporter polypeptide 1B1 (OATP1B1), organic cation transporters 1 ...
Supramolecular networks that consist of ordered arrangements of organic electron donor linkers (usually ditopic or polytopic organic carboxylates) and metal cations. They can have an extremely high surface area and adjustable pore size that allows for the insertion of other molecules capable of various functions such as catalysis, capture of carbon dioxide, and drug delivery.
Compounds derived from organic or inorganic acids in which at least one hydroxyl group is replaced by an –O-alkyl or other organic group. They can be represented by the structure formula RCOOR’ and are usually formed by the reaction between an acid and an alcohol with elimination of water.
A class of organic compounds known as sterols or STEROIDS derived from plants.
Organic compounds derived from BENZENE.
Neutral or negatively charged ligands bonded to metal cations or neutral atoms. The number of ligand atoms to which the metal center is directly bonded is the metal cation's coordination number, and this number is always greater than the regular valence or oxidation number of the metal. A coordination complex can be negative, neutral, or positively charged.
Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...