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Increased expression of miR-146a, miR-10b, and miR-21 in cancer stem-like gastro-spheres.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Increased expression of miR-146a, miR-10b, and miR-21 in cancer stem-like gastro-spheres."

Gastric cancer remains one of the leading causes of cancer-associated mortalities globally. Accumulating evidence support the presence of gastric cancer stem cells (CSCs) and their role in the pathogenesis and therapeutic challenges of gastric cancer. MicroRNAs (miRNAs) may be influenced by the cellular differentiative state and as critical regulators of the cellular fate in development and cancer, can modulate the behavior of CSCs too. Here, we aimed to investigate the expression relevance of three prognostic miRNAs (miR-21, miR-10b, and miR-146a) in CSCs of AGS and MKN-45 gastric cancer cell lines.

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This article was published in the following journal.

Name: Journal of cellular biochemistry
ISSN: 1097-4644
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