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mTOR inhibitors, new drugs for CTNNB1-mutated hepatocellular carcinomas?

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "mTOR inhibitors, new drugs for CTNNB1-mutated hepatocellular carcinomas?"

Knowledge of the genomic alterations of hepatocellular carcinomas (HCC) has significantly contributed to the understanding of the disease pathogenesis and provides the basis for personalized medicine (1). However, it is still a major challenge to translate this information into molecularly plausible and clinically safe therapeutic targets. Specifically, one of the most frequent mutations in HCC affects CTNNB1, encoding β-catenin, and results in an aberrant activation of the Wnt/β-catenin signalling (1). This article is protected by copyright. All rights reserved.

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Name: Hepatology (Baltimore, Md.)
ISSN: 1527-3350
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Medical and Biotech [MESH] Definitions

An adaptor protein, consisting of seven WD REPEATS along its length, that functions as a component of the MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1 and MTORC2 COMPLEX. It interacts directly with MTOR to enhance its kinase activity and stabilizes the MTOR-RPTOR PROTEIN interaction in nutrient-poor conditions, favoring RPTOR inhibition of MTOR activity.

A carcinoma composed mainly of epithelial elements with little or no stroma. Medullary carcinomas of the breast constitute 5%-7% of all mammary carcinomas; medullary carcinomas of the thyroid comprise 3%-10% of all thyroid malignancies. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1141; Segen, Dictionary of Modern Medicine, 1992)

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Compounds and drugs that inhibit or block the activity of CATECHOL O-METHYLTRANSFERASE enzymes. Drugs in this class are used in management of central nervous system disorders such as PARKINSON DISEASE.

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