A case of extramedullary hematopoiesis presenting as hemorrhagic panniculitis and evolving in acute myeloid leukemia.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "A case of extramedullary hematopoiesis presenting as hemorrhagic panniculitis and evolving in acute myeloid leukemia."

Extramedullary hematopoiesis (EMH) in adults is a rare event, usually associated with myeloid disorders, and can be the first sign of chronic myelomonocytic leukaemia. We report a case of EMH presenting as a hemorrhagic panniculitis in a patient who did not apparently present any myeloid disorders. The patient received previous chemotherapy for mantle cell lymphoma localized to the large bowel and had been in complete remission for three years. The diagnosis of EMH was achieved after a deep incisional biopsy of a nodule from the thigh, and with pathological examination that included immunohistochemical studies. After a follow-up of 14 months, the patient developed an acute myeloid leukemia, classified as therapy related myeloid neoplasm, according to the 2016 WHO classification of hematological malignancies. As shown by the rare cases described in literature, the presence of cutaneous EMH should always be a trigger for investigating the patient's hematological system; also, in our experience, a long follow-up is mandatory. This article is protected by copyright. All rights reserved.


Journal Details

This article was published in the following journal.

Name: Journal of cutaneous pathology
ISSN: 1600-0560


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