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Impact of drug-drug interactions on phenobarbital pharmacokinetics in pediatric patients-Response.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Impact of drug-drug interactions on phenobarbital pharmacokinetics in pediatric patients-Response."

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This article was published in the following journal.

Name: Epilepsia
ISSN: 1528-1167
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Medical and Biotech [MESH] Definitions

Agents that aid or increase the action of the principle drug (DRUG SYNERGISM) or that affect the absorption, mechanism of action, metabolism, or excretion of the primary drug (PHARMACOKINETICS) in such a way as to enhance its effects.

The action of a drug that may affect the activity, metabolism, or toxicity of another drug.

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Naturally occurring genetic variations associated with drug response (e.g., dosage, extent and rate of metabolic processes). While these variants are not markers for GENETIC PREDISPOSITION TO DISEASE they influence PHARMACOKINETICS and pharmacodynamics and often occur on genes encoding drug metabolism enzymes and transporters (e.g., ANGIOTENSIN CONVERTING ENZYME; CYTOCHROME P-450 CYP2D6).

The properties and processes of drug metabolism and drug interactions.

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