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Monitoring of new phenethylamine designer drugs in oral fluid (OF) is a crucial aim in workplace testing and driving under the influence of drug programs. In this study a simple and very quick method for the quantification of 11 illicit drugs in OF, which gave negative results to immunoassay tests, is proposed. Sample treatment and extraction of analytes were simultaneously achieved by applying supramolecular solvents (SUPRAS) tool. Chromatographic separation and compounds quantification were carried out by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis. Efficacy of cleaning-up/extraction of this SUPRAS approach was fully confirmed by recovery and matrix effect results. The entire analytical procedure was validated following the international guidelines. The SUPRAS extraction coupled with LC-MS/MS resulted in powerful tool for the control of phenethylamines abuse, with rapid run time and minimal sample preparation. The use of this methodology could be easily extended to monitoring of other drugs of abuse.
This article was published in the following journal.
Name: Journal of analytical toxicology
The use of new psychoactive substances as drugs of abuse has dramatically increased over the last years. Hallucinogenic phenethylamines gained particular popularity as they have both stimulating and p...
In this study, the application of a mixture of organic solvents as a supported liquid membrane for improving the efficiency of the electromembrane extraction procedure was investigated. The extraction...
The supramolecular assembly of C3-peptides carrying glycine-cysteine (Gly-Cys) dipeptide pendants into helical fibers is described. A Gly-Cys dipeptide sequence was selected to ensure the chirality, a...
The interest of food industry to merchandise natural astaxanthin is growing up. However, it confronts scientific and technological challenges mainly related to its poor water solubility and chemical i...
Wastewater-based epidemiology (WBE) has become a useful tool in long-term or short-term continuous monitoring of illicit drugs consumption over the world.
This Phase 1 STTR project will develop a technology platform for delivering the TAPS Tool to a Spanish-speaking, health disparity population in a community health center. This will involve...
Background: Substance abuse among children and adolescents is an important public health issue in Taiwan. Kaoshiung Chang Gung Memorial Hospital and Taiwan Kaoshiung Juvenile and Family Co...
Early ovarian reserve decreased is one of the main causes of infertility for women after 35 years. The relationship between this decreased and exposure to chemicals, including persistent e...
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Illicit use of chemicals and products whose vapors can be inhaled to produce a rapid mind-altering effect. Inhalants include aerosols, gases, and volatile solvents that are often inhaled repeatedly to achieve the short-lived intoxicating effect.
Isomeric forms and derivatives of hexanol (C6H11OH).
A diuretic and renal diagnostic aid related to sorbitol. It has little significant energy value as it is largely eliminated from the body before any metabolism can take place. It can be used to treat oliguria associated with kidney failure or other manifestations of inadequate renal function and has been used for determination of glomerular filtration rate. Mannitol is also commonly used as a research tool in cell biological studies, usually to control osmolarity.
Review of claims by insurance companies to determine liability and amount of payment for various services. The review may also include determination of eligibility of the claimant or beneficiary or of the provider of the benefit; determination that the benefit is covered or not payable under another policy; or determination that the service was necessary and of reasonable cost and quality.
Validation of the sex of an individual by means of the bones of the SKELETON. It is most commonly based on the appearance of the PELVIS; SKULL; STERNUM; and/or long bones.
Multiple Sclerosis MS
Multiple sclerosis (MS) is the most common disabling neurological condition affecting 100,000 young adults in the UK. The condition results from autoimmune damage to myelin, causing interference in nerve signaling. Symptoms experienced depend on the pa...
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...