Application of transition metal ions in a study of photoinduced modifications of melanin.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Application of transition metal ions in a study of photoinduced modifications of melanin."

Short wavelength visible light is viewed as the main agent responsible for oxidative modification of melanin in the human retinal pigment epithelium (RPE). The aim of this research was to study light-induced modifications of melanin using iron and zinc as molecular probes. A synthetic model of eumelanin was treated by intense violet light. The interaction of melanin with metal ions was examined by electron paramagnetic resonance (EPR) spectroscopy and a thiocyanate assay. Weak photodegradation of melanin was shown to increase exposure of melanin subunits, while stronger photodegradation caused a loss of melanin subunits. Iron-binding in such melanin was weak and nonspecific.


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This article was published in the following journal.

Name: Acta biochimica Polonica
ISSN: 1734-154X


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