High Frequency Spinal Cord Stimulation in a Sub-Acute Animal Model of Spinal Cord Injury.

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Summary of "High Frequency Spinal Cord Stimulation in a Sub-Acute Animal Model of Spinal Cord Injury."

High Frequency Spinal Cord Stimulation (HF-SCS) applied at the T2 spinal level results in physiologic activation of the inspiratory muscles in C2 spinal sectioned dogs. While the bulbo-spinal fibers were cut, they likely survived the duration of acute experiments and inspiratory muscle activation may have involved stimulation of these fibers. In 2 anesthetized, C2 paralyzed, intubated and mechanically ventilated dogs, HF-SCS (300Hz) was applied at the T2 level. The effectiveness of HF-SCS in generating inspired volume (V) and negative airway pressures (P) was evaluated over a period of 5 days during which time the bulbo-spinal fibers would have degenerated. Since the effectiveness of HF-SCS may be adversely affected by deterioration of these fibers and/or the condition of the animal, low frequency (50Hz) SCS (LF-SCS) was also performed and served as a control. All vital signs, oxygen saturation and end-tidal PCO remained stable over the 5-day period. V and P also remained stable over the study period. For example, mean V and P were 771±25ml and 64±1cmHO with HF-SCS (3mA) during the initial and 674±59ml and 63±5cmHO on the final day. Comparable values during LF-SCS (8mA) were 467±12ml and 48±1cmHO during the initial and 397±20ml and 42±2cmHO on the final day. Since V and P in response to HF-SCS remained stable over a 5-day period following which the bulbo-spinal fibers would have degenerated, the mechanism of HF-SCS does not depend upon the viability of these tracts. HF-SCS therefore may be a useful method to restore ventilation in chronic ventilator dependent tetraplegics.


Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601


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Medical and Biotech [MESH] Definitions

Application of electric current to the spine for treatment of a variety of conditions involving innervation from the spinal cord.

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Reduced blood flow to the spinal cord which is supplied by the anterior spinal artery and the paired posterior spinal arteries. This condition may be associated with ARTERIOSCLEROSIS, trauma, emboli, diseases of the aorta, and other disorders. Prolonged ischemia may lead to INFARCTION of spinal cord tissue.

Acute and chronic conditions characterized by external mechanical compression of the SPINAL CORD due to extramedullary neoplasm; EPIDURAL ABSCESS; SPINAL FRACTURES; bony deformities of the vertebral bodies; and other conditions. Clinical manifestations vary with the anatomic site of the lesion and may include localized pain, weakness, sensory loss, incontinence, and impotence.

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