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High Frequency Spinal Cord Stimulation in a Sub-Acute Animal Model of Spinal Cord Injury.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "High Frequency Spinal Cord Stimulation in a Sub-Acute Animal Model of Spinal Cord Injury."

High Frequency Spinal Cord Stimulation (HF-SCS) applied at the T2 spinal level results in physiologic activation of the inspiratory muscles in C2 spinal sectioned dogs. While the bulbo-spinal fibers were cut, they likely survived the duration of acute experiments and inspiratory muscle activation may have involved stimulation of these fibers. In 2 anesthetized, C2 paralyzed, intubated and mechanically ventilated dogs, HF-SCS (300Hz) was applied at the T2 level. The effectiveness of HF-SCS in generating inspired volume (V) and negative airway pressures (P) was evaluated over a period of 5 days during which time the bulbo-spinal fibers would have degenerated. Since the effectiveness of HF-SCS may be adversely affected by deterioration of these fibers and/or the condition of the animal, low frequency (50Hz) SCS (LF-SCS) was also performed and served as a control. All vital signs, oxygen saturation and end-tidal PCO remained stable over the 5-day period. V and P also remained stable over the study period. For example, mean V and P were 771±25ml and 64±1cmHO with HF-SCS (3mA) during the initial and 674±59ml and 63±5cmHO on the final day. Comparable values during LF-SCS (8mA) were 467±12ml and 48±1cmHO during the initial and 397±20ml and 42±2cmHO on the final day. Since V and P in response to HF-SCS remained stable over a 5-day period following which the bulbo-spinal fibers would have degenerated, the mechanism of HF-SCS does not depend upon the viability of these tracts. HF-SCS therefore may be a useful method to restore ventilation in chronic ventilator dependent tetraplegics.

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This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
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