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The effect of acute dietary nitrate supplementation on sympathetic vasoconstriction at rest and during exercise.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "The effect of acute dietary nitrate supplementation on sympathetic vasoconstriction at rest and during exercise."

Dietary nitrate (NO) supplementation has been shown to reduce resting blood pressure (BP). However, the mechanism(s) responsible for the reduction in BP has not been identified. Dietary NO supplementation may increase nitric oxide (NO) bioavailability and NO has been shown to inhibit sympathetic vasoconstriction. Therefore, the purpose of this study was to investigate the hypothesis that acute dietary NO supplementation would attenuate sympathetic vasoconstrictor responsiveness at rest and during exercise. In a double-blind randomized crossover design, 12 men performed a cold-pressor test (CPT) at rest and during moderate- and heavy-intensity alternate-leg knee-extension exercise after consumption of NO rich beetroot juice (~12.9 mmol NO) or a NO-depleted placebo (~0.13 mmol NO). Venous blood was sampled before and 2.5 hours after consumption of beetroot juice to measure total plasma nitrite/nitrate [NOx]. BP was measured by Finometer. Leg blood flow (LBF) was measured at the femoral artery via Doppler ultrasound and leg vascular conductance (LVC) was calculated. Sympathetic vasoconstrictor responsiveness was calculated as the percentage decrease in LVC in response to the CPT. Total plasma [NOx] was greater (p<0.001) in the NO compared to the placebo condition. However, blood pressure and plasma catecholamines were not different (p>0.05) between NO and placebo conditions at rest or during exercise. Sympathetic vasoconstrictor responsiveness (Δ % LVC) was not different (p>0.05) between NO and placebo conditions at rest or during moderate- and heavy-intensity exercise. These data demonstrate that acute dietary nitrate supplementation does not alter sympathetic vasoconstrictor responsiveness at rest and during exercise in young healthy males.

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This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Pages:

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An iron-sulfur and MOLYBDENUM containing FLAVOPROTEIN that catalyzes the oxidation of nitrite to nitrate. This enzyme can use either NAD or NADP as cofactors. It is a key enzyme that is involved in the first step of nitrate assimilation in PLANTS; FUNGI; and BACTERIA. This enzyme was formerly classified as EC 1.6.6.2.

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