08:00 EDT 16th May 2019 | BioPortfolio


This review strikes at the very heart of how the microcirculation functions to facilitate blood-tissue oxygen, substrate and metabolite fluxes in skeletal muscle. Contemporary evidence, marshalled from animals and humans using the latest techniques, challenges iconic perspectives little-changed over the past century. Those perspectives include: The presence of contractile or collapsible capillaries in muscle, unitary control by pre-capillary sphincters, capillary recruitment at the onset of contractions and the notion of capillary-to-mitochondrial diffusion distances as limiting O delivery. Today a wealth of physiological, morphological and intravital microscopy evidence presents a completely different picture of microcirculatory control. Specifically, capillary red blood cell (RBC) and plasma flux is controlled primarily at the arteriolar level with most capillaries, in healthy muscle, supporting at least some flow at rest. In healthy skeletal muscle this permits substrate access (whether carried in RBCs or plasma) to a prodigious total capillary surface area. Pathologies such as heart failure or diabetes decrease access to that exchange surface by reducing the proportion of flowing capillaries at rest and during exercise. Capillary morphology and function vary disparately among tissues. The contemporary model of capillary function explains how, following the onset of exercise, muscle O uptake kinetics can be extremely fast in health but slowed in heart failure and diabetes impairing contractile function and exercise tolerance. Adoption of this model is fundamental for understanding microvascular function and dysfunction and, as such, to the design and evaluation of effective therapeutic strategies to improve exercise tolerance and decrease morbidity and mortality in disease.


Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601


DeepDyve research library

PubMed Articles [13414 Associated PubMed Articles listed on BioPortfolio]

Effect of the use of a model with peer instruction for the teaching of membrane potential and action potential.

A group of teachers from Northeast Brazil developed a model of membrane potentials and action potential and tested the hypothesis that using the peer-instruction model would provide a better performan...

Effectiveness of shifting traditional lecture to interactive lecture to teach nursing students.

This study was conducted to examine effectiveness of interactive lecture in teaching nursing students compared to traditional lecture.

The relation between central variables, electromyography signals and peripheral microcirculation during intensive treadmill exercise.

Aerobic exercise under muscle fatigue can lead to muscular damage and injuries. Finding the correlations between central and peripheral microcirculation variables, as well as with electromyography sig...

The LXXV Edward Jackson Memorial Lecture: Lessons Learned from Avastin and OCT: The Great, The Good, The Bad, and The Ugly.

To describe the synergistic benefits and cost-savings from the use of optical coherence tomography (OCT) and vascular endothelial growth factor (VEGF) inhibitors, particularly intravitreal bevacizumab...

Skeletal muscle performance in metabolic disease: microvascular or mitochondrial limitation or both?

One of the clearly established health outcomes associated with chronic metabolic diseases (e.g., type II diabetes mellitus) is that the ability of skeletal muscle to maintain contractile performance d...

Clinical Trials [5409 Associated Clinical Trials listed on BioPortfolio]

Strength Training for Elderlies and Their Effects on Muscle Fatigue and Microcirculation - Randomized Clinical Trial

The purpose of this study is to verify the effects of a strength training program on functional capacity, muscle performance and microcirculation in the elderly.

Impact of Ranolazine on Coronary Microcirculatory Resistance

This study is being done to determine if Ranolazine treatment improves coronary microcirculation function among patients with coronary microcirculation dysfunction. We are also looking to ...

Identification of Microcirculation and Inflammation After Posterior Stabilization of the Spine

In this project, with unstable vertebral fractures, the microcirculation of the skin and muscle (O2C,Laser-Doppler/White-light -Spectroscopy and contrast-enhanced sonography) will be evalu...

Spread of Muscle Hyperalgesia and Pain in a Low Dose NGF-induced Pain Model

The purpose of this study is to investigate and determine the time course and distribution on muscle hyperalgesia and muscle pain in a repeated, low dose NGF model. It is hypothesized that...

Microcirculation of Patients With Kidney Transplant

This study measures the sublingual microcirculation of patients with kidney transplant using MicroScan. The data will be compared with data of health volunteers and end stage renal disease...

Medical and Biotech [MESH] Definitions

Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.

An island in the Gulf of St. Lawrence constituting a province of Canada in the eastern part of the country. It is very irregular in shape with many deep inlets. Its capital is Charlottetown. Discovered by the French in 1534 and originally named Ile Saint-Jean, it was renamed in 1799 in honor of Prince Edward, fourth son of George III and future father of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p981 & Room, Brewer's Dictionary of Names, 1992, p433)

Theoretical models simulating behavior or activities in nursing, including nursing care, management and economics, theory, assessment, research, and education. Some examples of these models include Orem Self-Care Model, Roy Adaptation Model, and Rogers Life Process Model.

Works consisting of notes taken at the delivery or reading of a speech before an audience or class, usually given to instruct. (From Random House Unabridged Dictionary, 2d ed)

A principle of estimation in which the estimates of a set of parameters in a statistical model are those quantities minimizing the sum of squared differences between the observed values of a dependent variable and the values predicted by the model.

Quick Search


DeepDyve research library

Relevant Topics

Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...

Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Searches Linking to this Article