Advertisement

Topics

1-D Network Simulations for Evaluating Regional Flow and Pressure Distributions in the Healthy and Asthmatic Human Lungs.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "1-D Network Simulations for Evaluating Regional Flow and Pressure Distributions in the Healthy and Asthmatic Human Lungs."

This study aims to introduce a 1-D computational fluid dynamics (CFD) model for airway resistance and lung compliance to examine the relationship between airway resistance, pressure, and regional flow distribution. We employed five healthy and five asthmatic subjects who have dynamic CT scans (4-D CT) along with two static scans at total lung capacity and functional residual capacity. Fractional air-volume change (ΔV) from 4-D CT was used for a validation of the 1-D CFD model. We extracted diameter ratio from existing datasets of 61 healthy subjects for computing mean and standard deviation (SD) of airway constriction/dilation in CT-resolved airways. The lobar mean (SD) of airway constriction/dilation was used to determine diameters of CT unresolved airways. An 1-D isothermal energy balance equation was solved, and pressure boundary conditions were imposed at the acinar region (Model A) or at the pleural region (Model B). A static compliance model was only applied for Model B to link acinar and pleural regions. The values of 1-D CFD-derived ΔV for Model B demonstrated better correlation with 4-D CT-derived ΔV than Model A. In both inspiration and expiration, asthmatics with airway constriction show much greater pressure drop than healthy subjects without airway constriction. This increased transpulmonary pressures in the asthmatics, leading to an increased work-load (hysteresis). The 1-D CFD model was found to be useful in investigating flow-structure, lung hysteresis, and pressure distribution for healthy and asthmatic subjects. The derived flow distribution could be used for imposing boundary condition of 3-D CFD.

Affiliation

Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Pages:

Links

DeepDyve research library

PubMed Articles [21275 Associated PubMed Articles listed on BioPortfolio]

Toward Understanding Cerebral Blood Flow during Cardiopulmonary Bypass: Implications for the Central Nervous System.

Factors and Their Influence on Regional Cerebral Blood Flow during Nonpulsatile Cardiopulmonary Bypass. By Govier AV, Reves JG, McKay RD, Karp RB, Zorn GL, Morawetz RB, Smith LR, Adams M, and Freeman ...

An In-Vitro Flow Study Using an Artificial Circle of Willis Model for Validation of an Existing One-Dimensional Numerical Model.

A one-dimensional (1D) numerical model has been previously developed to investigate the hemodynamics of blood flow in the entire human vascular network. In the current work, an experimental study of w...

Enhanced water transport through a carbon nanotube controlled by the lateral pressure.

The transport of water through carbon nanotubes is now of great importance in bionanotechnology and of considerable interest for potential nanofluidic applications. In this paper, we show by molecular...

Airflow limitation in a collapsible model of the human pharynx: physical mechanisms studied with fluid-structure interaction simulations and experiments.

The classical Starling Resistor model has been the paradigm of airway collapse in obstructive sleep apnea (OSA) for the last 30 years. Its theoretical framework is grounded on the wave-speed flow lim...

Regional cerebral hypoperfusion after acute sleep deprivation: A STROBE-compliant study of arterial spin labeling fMRI.

Previous neuroimaging studies have shown that functional changes occur after acute sleep deprivation, which suggest detrimental effects of a lack of sleep on the intrinsic functional architecture of t...

Clinical Trials [15891 Associated Clinical Trials listed on BioPortfolio]

reGional Network for Acute Myocardial Infarction

Incidence of ST-segment Elevation Myocardial Infarction(STEMI) is rising and the existing emergency medical aid system for STEMI was not enough for timely perfusion treatment. No existing ...

Regional Ventilation During High Flow Nasal Cannula and Conventional Nasal Cannula in Patients With Hypoxia

High-flow nasal cannula (HFNC) that uses heated and humidified oxygen was recently introduced for bedside care. It has been shown to be associated with reduced risks of tracheal intubation...

Regional Lung Opening and Closing Pressures in Patients With Acute Lung Injury

The purpose of this study is the measurement of regional opening and closing pressures of lung tissue by electrical impedance tomography in lung healthy and patients with acute lung injury...

Monitoring of Injection Pressure During Regional Anesthesia in Pediatric Patient

A low injection pressure is one of the safety elements to check the correct position of the needle during regional anesthesia. Subjective assessment of pressure during manual injection of ...

Effect of Sodium Nitroprusside on Cerebral Blood Flow

The brain has a high energy demand and requires continuous blood flow. The blood flow to the brain appears to be unaffected by small changes in blood pressure, but brain blood flow may be ...

Medical and Biotech [MESH] Definitions

The flow of BLOOD through or around an organ or region of the body.

The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.

Process of evaluating the health of a patient and determining if they are healthy enough for surgery.

Physiologically, the opposition to flow of air caused by the forces of friction. As a part of pulmonary function testing, it is the ratio of driving pressure to the rate of air flow.

Methods for visualizing REGIONAL BLOOD FLOW, metabolic, electrical, or other physiological activities in the CENTRAL NERVOUS SYSTEM using various imaging modalities.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topic

Pulmonary
Pulmonary relating to or associated with the lungs eg Asthma, chronic bronchitis, emphysema, COPD, Cystic Fibrosis, Influenza,  Lung Cancer, Pneumonia, Pulmonary Arterial Hypertension, Sleep Disorders etc Follow and track Lung Cancer News ...


Searches Linking to this Article