Relationship between brachial and popliteal artery low-flow mediated constriction in older adults: Impact of aerobic fitness on vascular endothelial function.

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Summary of "Relationship between brachial and popliteal artery low-flow mediated constriction in older adults: Impact of aerobic fitness on vascular endothelial function."

We previously observed that brachial artery (BA) low-flow mediated constriction (L-FMC) is inversely related to aerobic fitness (i.e., VOpeak) in older adults (OA). However, it is unclear if an L-FMC response is elicited in the popliteal artery (POP) or if a similar inverse relationship with aerobic fitness exists. Considering that the POP experiences larger shear stress fluctuations during sedentary behaviors and traditional lower limb modes of aerobic exercise, we tested the hypotheses that: 1) heterogeneous L-FMC responses exist between the BA vs. POP of OA, and 2) that aerobic fitness will be inversely related to POP L-FMC. L-FMC was assessed in 47 healthy OA (30♀, 67 ± 5 yr) using duplex ultrasonography and quantified as the percent decrease in diameter (from baseline) during the last 30 s of a 5 min distal cuff occlusion period. When allometrically scaled to baseline diameter, the BA exhibited a greater L-FMC response than the POP (-1.3±1.6% vs. -0.4±1.6%; =0.03). Furthermore, L-FMC responses in the BA and POP were not correlated (r=0.22; =0.14). VOpeak was strongly correlated to POP L-FMC (r=-0.73; <0.001). The heterogeneous BA versus POP L-FMC data indicate that upper limb L-FMC responses do not represent a systemic measure of endothelial-dependent vasoconstrictor capacity in OA. The strong association between VOpeak and POP L-FMC suggests that localized shear stress patterns, perhaps induced by lower limb dominant modes of aerobic exercise, may result in greater vasoconstrictor responsiveness in healthy OA.


Journal Details

This article was published in the following journal.

Name: Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601


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Medical and Biotech [MESH] Definitions

The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.


The direct continuation of the brachial trunk, originating at the bifurcation of the brachial artery opposite the neck of the radius. Its branches may be divided into three groups corresponding to the three regions in which the vessel is situated, the forearm, wrist, and hand.

The larger of the two terminal branches of the brachial artery, beginning about one centimeter distal to the bend of the elbow. Like the RADIAL ARTERY, its branches may be divided into three groups corresponding to their locations in the forearm, wrist, and hand.

The continuation of the axillary artery; it branches into the radial and ulnar arteries.

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