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Role of Oligoethylene Glycol Side Chain Length in Responsive Polymeric Nanoassemblies.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Role of Oligoethylene Glycol Side Chain Length in Responsive Polymeric Nanoassemblies."

An oft-desired feature of a responsive nanomaterial is for it to undergo disassembly or morphological change upon application of a specific stimulus. The extent of response has been found to depend on factors such as the nature and the number of responsive functionalities incorporated into these particles. In this work, the length of oligoethyleneglycol (OEG) side chains associated with the polymers has been shown to greatly influence the responsive behavior of polymeric nanoparticles. The integrity of these OEG-based polymeric assemblies was found to depend not only on the chemical crosslinks, but also on the physical crosslinks in these aggregates in cases where the polymer chains bear long OEG side chains. The physical crosslinking in longer OEG side chain containing polymeric nanogels are present in the form of crystalline domains. Our results here highlight that these ethyleneglycol-based hydrophilic units are not to be ignored as spectator units with water-solubilization characteristics, but must be analyzed in the context of assembly stabilization and triggerability with the targeted stimulus.

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This article was published in the following journal.

Name: Langmuir : the ACS journal of surfaces and colloids
ISSN: 1520-5827
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