Synthesis of α-Fluorinated Imides via Direct Fluorohydroxylation of Ynamides.

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Summary of "Synthesis of α-Fluorinated Imides via Direct Fluorohydroxylation of Ynamides."

A practical synthesis of α-fluorinated imides via the catalyst-free fluorohydroxylation of ynamides is developed. The reaction employs commercially available Selectfluor (F-TEDA-BF) and HO as the fluorine and hydroxyl sources, respectively. A broad range of aryl- or alkyl-substituted ynamides were well applicable to the reaction with good functional group tolerance under simple and mild reaction conditions. The synthetic utility of the α-fluoroimide products was demonstrated by several value-added transformations. Preliminary mechanistic studies were conducted.


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Name: Organic letters
ISSN: 1523-7052


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