Track topics on Twitter Track topics that are important to you
An open air ruthenium(VIII)-catalyzed oxidative spiro-etherification as well as spiro-amidation of phenols has been performed. The transformation works satisfactorily with both phenols and naphthols and thus exhibits a wide range of flexibility. The catalysis is performed in open air at room temperature with a yield of ≤95%.
This article was published in the following journal.
Name: Organic letters
The three-component reaction of 1,3-indanedione and N-alkylisatins with two molecular N-phenacylpyridinium salts in dry acetonitrile in the presence of triethylamine resulted in unique functionalized ...
The syntheses of the novel amino alcohols MeN(CH2CH2CMe2OH)2 (1), MeN(CMe2CH2OH) (CH2CMe2OH) (2), MeN(CH2CH2CH2OH)(CH2CMe2OH) (3), MeN(CH2CH2CMe2OH)(CH2CMe2OH) (4), MeN (CH2CH2CMe2OH)(CH2CH2OH) (5) an...
Copper-catalysed one-pot multicomponent protocol has been developed for construction of spiro heterocycles. The domino approach, leads to synthesis of spiro oxazolidinones starting from ketones, aryla...
A highly stereoselective synthesis of a spiro-cineole scaffold that contains four stereogenic centers from readily accessible 2-alkynylbenzaldehydes and styrenes under very mild reaction conditions wa...
Armeniaspirols are potent antibiotics containing an unusual spiro[4.4]non-8-ene moiety. We describe the cloning and functional analysis of the armeniaspirol biosynthetic gene cluster. Gene inactivatio...
Problematic: Spirometry is used to objectify the obstructive syndrome defining chronic obstructive pulmonary disease (COPD). However, this test remains underused in the primary care. The t...
1. To compare the efficacy and safety of PK-guided treatment with BAX 855 targeting FVIII trough levels of 1-3% and approximately 10% (8-12%) 2. To further characterize pharmacokin...
Hemophilia A is a genetic deficiency of factor VIII that causes blood to clot too slowly. The disease is classified based on how much factor VIII is in the blood. People with mild or moder...
Part A of the study will compare the pharmacokinetics (bioequivalence) of a new formulation of Kogenate (recombinant Factor VIII) with the current formulation. Part B will evaluate the sa...
The primary objective of this study is to determine the pharmacokinetic profile after single administration of two doses of BAY 79-4980 (high and low: 35 IU FVIII/Kg reconstituted in 22 mg...
A group of compounds consisting in part of two rings sharing one carbon atom in common.
A spiro butyrophenone analog similar to HALOPERIDOL and other related compounds. It has been recommended in the treatment of SCHIZOPHRENIA.
A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as antineoplastic agents.
Unstable isotopes of ruthenium that decay or disintegrate emitting radiation. Ru atoms with atomic weights 93-95, 97, 103, and 105-108 are radioactive ruthenium isotopes.