A Photoredox/Cobalt-Catalyzed Phosphinyloxy Radical addition/Cyclization Cascade: Synthesis of Phosphaisocoumarins.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "A Photoredox/Cobalt-Catalyzed Phosphinyloxy Radical addition/Cyclization Cascade: Synthesis of Phosphaisocoumarins."

A novel visible-light photoredox catalyzed phosphinyloxy radical addition/cyclization cascade of arylphosphinic acids or arylphosphonic acid monoesters with alkynes has been developed, which provides an efficient and practical access to various phosphaisocoumarins by using a dual catalytic system containing an acridinium photosensitizer and a cobaloxime proton-reducing catalyst, [Co(dmgH)2]PyCl at ambient temperature. This method has advantages of broad substrate scope, mild condition as well as without any sacrificial oxidant.


Journal Details

This article was published in the following journal.

Name: The Journal of organic chemistry
ISSN: 1520-6904


DeepDyve research library

PubMed Articles [7152 Associated PubMed Articles listed on BioPortfolio]

Copper-Catalyzed Radical Cascade Cyclization to Access 3-Sulfonated Indenones with AIE Phenomenon.

An efficient copper-catalyzed radical cascade cyclization strategy was developed, by which a wide variety of 3-sulfonyl substituted indenones were prepared in one-pot via reaction of 2-alkynylbenzonit...

Generation of 1,3-Dimethylene-Substituted Isobenzofurans via Pd(II)-Catalyzed Selective oxo-Cyclization/SO2 Insertion Cascade of β-Alkynyl Ketones.

A new palladium(II)-catalyzed cyclization-radical addition cascade enables the direct construction of 1,3-dimethylene-substituted isobenzofuran derivatives containing vinyl aryl sulfone unit in good y...

Synthesis of Benzofuran Derivatives via Cascade Radical Cyclization/Intermolecular Coupling of 2-Azaallyls.

Benzofurans are among the most abundant structural units in bioactive natural products. However, the synthesis of such structures by radical cyclization cascade reactions is rare. Herein we report a m...

Photoredox/Nickel-Catalyzed Single-Electron Tsuji-Trost Reaction: Development and Mechanistic Insight.

A regioselective, nickel-catalyzed photoredox allylation of secondary, benzyl, and α-alkoxy radical precursors is disclosed. Through this manifold, a variety of linear allylic alcohols and allylated ...

Cobalt-Catalyzed Enantioselective Hydroboration/Cyclization of 1,7-Enynes: Asymmetric Synthesis of Chiral Quinolinones Containing Quaternary Stereogenic Centers.

An asymmetric cobalt-catalyzed hydroboration/cyclization of 1,7-enynes to synthesize chiral six-membered N-heterocyclic compounds was developed. A variety of aniline-tethered 1,7-enynes react with pin...

Clinical Trials [2022 Associated Clinical Trials listed on BioPortfolio]

A Comparison Between Titanium Femoral Stem and Cobalt-Chromium Femoral Stem in Cemented Hip Arthroplasty

In this randomised study, the migration of a specific cemented titanium femoral stem will be compared with a similar cemented cobalt-chromium stem using Roentgen stereogrammetric analysis ...

Comparison Between Injection Molded PEEK Framework and Cobalt Chromium Framework in Removable Partial Denture Regarding Retention

This study is aiming to evaluate the retentive forces in PEEK framework RPD compared to Cobalt-Chrome framework RPD during attachment/detachment cycles in mandibular kennedy class I edentu...

The ACTIVE (Use of the Assurant® Cobalt Iliac Stent System in the Treatment of Iliac Vessel Disease) Study

The objective of this study is to evaluate the safety and efficacy of the Assurant Cobalt Iliac Stent System in the treatment of de novo and restenotic lesions in iliac arteries of subject...

Study to Evaluate the Safety of Cronus® - Cobalt Chromium Coronary Stent

The objective this study is evaluate the performance and safety of Chronus® cobalt-chromium coronary stent in patients with "de novo" native coronary artery lesions treated with 19-mm-lon...

Serum Cobalt Status During Pregnancy and the Risks of PIH

The subjects of the present study were from the Ma'anshan Birth Cohort (MABC) study, a prospective pregnancy and birth cohort study designed to examine the relationship between prenatal ex...

Medical and Biotech [MESH] Definitions

A technique for detecting short-lived reactive FREE RADICALS in biological systems by providing a nitrone or nitrose compound for an addition reaction to occur which produces an ELECTRON SPIN RESONANCE SPECTROSCOPY-detectable aminoxyl radical. In spin trapping, the compound trapping the radical is called the spin trap and the addition product of the radical is identified as the spin adduct. (Free Rad Res Comm 1990;9(3-6):163)

Stable cobalt atoms that have the same atomic number as the element cobalt, but differ in atomic weight. Co-59 is a stable cobalt isotope.

Unstable isotopes of cobalt that decay or disintegrate emitting radiation. Co atoms with atomic weights of 54-64, except 59, are radioactive cobalt isotopes.

The addition of an organic acid radical into a molecule.

The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.

Quick Search


DeepDyve research library

Searches Linking to this Article