Canalicular Junctions in the Osteocyte Lacuno-Canalicular Network of Cortical Bone.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Canalicular Junctions in the Osteocyte Lacuno-Canalicular Network of Cortical Bone."

The osteocyte lacuno-canalicular network (LCN) is essential for bone remodeling since osteocytes regulate cell recruitment. This has been proposed to occur through liquid flow induced shear forces in the canaliculi. Models of the LCN have thus far assumed that it contains canaliculi connecting the osteocyte lacunae. However, here we reveal that enlarged spaces occur at places where several canaliculi cross; we name these spaces canalicular junctions. We characterize them in detail within mice cortical bone using synchrotron nanotomography at two length scales, with 50 nm and 130 nm voxel size, and show that canalicular junctions occur at a density similar to that of osteocyte lacunae and that canalicular junctions tend to cluster. Through confocal laser scanning microscopy we show that canalicular junctions are widespread as we have observed them in cortical bone from several species even though the number density of the canalicular junctions was not universal. Fluid flow simulations of a simple model system with and without a canalicular junction, clearly shows that liquid mass transport and flow velocities are altered by the presence of canalicular junctions. We suggest that these canalicular junctions may play an important role in osteocyte communication and possibly also in canalicular fluid flow. Therefore, we believe that they constitute an important component in the bone osteocyte network.


Journal Details

This article was published in the following journal.

Name: ACS nano
ISSN: 1936-086X


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