Incorporating spatial-anatomical similarity into the VGWAS framework for AD biomarker detection.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Incorporating spatial-anatomical similarity into the VGWAS framework for AD biomarker detection."

The detection of potential biomarkers of Alzheimer's disease (AD) is crucial for its early prediction, diagnosis, and treatment. Voxelwise genome-wide association study (VGWAS) is a commonly used method in imaging genomics and usually applied to detect AD biomarkers in imaging and genetic data. However, existing VGWAS methods entail large computational cost and disregard spatial correlations within imaging data. A novel method is proposed to solve these issues.


Journal Details

This article was published in the following journal.

Name: Bioinformatics (Oxford, England)
ISSN: 1367-4811


DeepDyve research library

PubMed Articles [9681 Associated PubMed Articles listed on BioPortfolio]

Spatial correlations exploitation based on nonlocal voxel-wise GWAS for biomarker detection of AD.

Potential biomarker detection is a crucial area of study for the prediction, diagnosis, and monitoring of Alzheimer's disease (AD). The voxelwise genome-wide association study (vGWAS) is widely used i...

Fast and Robust Symmetric Image Registration Based on Distances Combining Intensity and Spatial Information.

Intensity-based image registration approaches rely on similarity measures to guide the search for geometric correspondences with high affinity between images. The properties of the used measure are vi...

Patch spaces and fusion strategies in patch-based label fusion.

In the field of multi-atlas segmentation, patch-based approaches have shown promising results in the segmentation of biomedical images. In the most common approach, registration is used to warp the at...

A novel telecoupling framework to assess social relations across spatial scales for ecosystem services research.

Access to ecosystem services and influence on their management are structured by social relations among actors, which often occur across spatial scales. Such cross-scale social relations can be analys...

What explains sex differences in math anxiety? A closer look at the role of spatial processing.

A large body of research has documented that females experience more math anxiety than males. Researchers have identified many factors that might explain the relation between sex and math anxiety. In ...

Clinical Trials [3204 Associated Clinical Trials listed on BioPortfolio]

Comparison Between Injection Molded PEEK Framework and Cobalt Chromium Framework in Removable Partial Denture Regarding Retention

This study is aiming to evaluate the retentive forces in PEEK framework RPD compared to Cobalt-Chrome framework RPD during attachment/detachment cycles in mandibular kennedy class I edentu...

Hearing and Vestibular Interactions in the Collection of Own Body and Sense of Self

The investigators objective is twofold. Investigators propose to study how the vestibular and auditory information interact in the construction of coherence between the staff and extrapers...

Spatial Cognitive Training

This study is designed to see if doing regular training on a spatial imagery task leads to improvements in the ability to do the trained spatial imagery task and in the ability to get arou...

Phase 1 Study of Trastuzumab Administered as a Single Intravenous Infusion

The primary objective of this study was to demonstrate pharmacokinetic similarity of Mylan trastuzumab (Hercules) versus EU-approved Herceptin® and US-licensed Herceptin® and pharmacokin...

Vestibular Disorder and Visuo-spatial Functions in Deaf Children

The purpose of this study is to determine whether vestibular disorders could affect visuo-spatial cognition. Visuo-spatial cognition will be evaluated using a new computerized test using a...

Medical and Biotech [MESH] Definitions

Methods used to take into account and incorporate spatial autocorrelation and regional variation into regression analysis models of data that has spatial dependency, and also to provide information on the spatial relationships among the variables.

Integration of spatial information perceived by visual and/or auditory CUES.

A process through which individuals encode information about their environmental CUES to facilitate SPATIAL NAVIGATION.

Memory related to spatial information.

The N-glucuronide conjugate of cotinine is a major urinary metabolite of NICOTINE. It thus serves as a biomarker of exposure to tobacco SMOKING. It has CNS stimulating properties.

Quick Search


DeepDyve research library

Relevant Topics

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Searches Linking to this Article