Adult Coats' Disease, Dubin-Johnson Syndrome, and the Search for Targeted Therapies.

08:00 EDT 1st May 2019 | BioPortfolio

Summary of "Adult Coats' Disease, Dubin-Johnson Syndrome, and the Search for Targeted Therapies."

Coats' disease is nonhereditary retinal vascular disorder characterized by telangiectatic retinal vessels with prominent aneurysmal changes and exudation. A conclusive etiology has not yet been determined. In this retrospective case report and literature review, a 64-year-old male with Dubin-Johnson syndrome presented with unilateral retinal vascular changes and exudation consistent with a diagnosis of adult Coats' disease. The authors conclude that patients with Dubin-Johnson syndrome carry mutations in a multidrug resistance associated protein (MRP). MRPs are also expressed in the retina, retinal pigment epithelium, and vascular endothelium, where they export toxins and metabolites, and may serve as a therapeutic target. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:318-321.].


Journal Details

This article was published in the following journal.

Name: Ophthalmic surgery, lasers & imaging retina
ISSN: 2325-8179
Pages: 318-321


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