Author's reply to 'The role of long-term effects of allopurinol on cardiovascular outcomes and all-cause mortality in diabetes'.

08:00 EDT 21st May 2019 | BioPortfolio

Summary of "Author's reply to 'The role of long-term effects of allopurinol on cardiovascular outcomes and all-cause mortality in diabetes'."

Our study found an association between allopurinol and reduced risk of mortality and cardiovascular outcomes in subjects with diabetes. However, although this association was observed in analyses that classified time as exposed or unexposed to allopurinol and in analyses that classified time according to current dose categories, we found no association in analyses classifying time according to cumulative allopurinol dose. This article is protected by copyright. All rights reserved.


Journal Details

This article was published in the following journal.

Name: Diabetes, obesity & metabolism
ISSN: 1463-1326


DeepDyve research library

PubMed Articles [35650 Associated PubMed Articles listed on BioPortfolio]

The role of long-term effects of allopurinol on cardiovascular outcomes and all-cause mortality in diabetes.

Long-term effects of opioids on the cardiovascular system: Examine the evidence.

This article provides an integrative review of the literature on long-term opioid use, its effects on the cardiovascular system, and its implications for nurses.

Hypersensitivity and cardiovascular risks related to allopurinol and febuxostat therapy in Asians: A population-based cohort study and meta-analysis.

The safety of newer xanthine oxidase inhibitor-febuxostat comparing to allopurinol remains unclear. To compare the risks of allopurinol- and febuxostat-hypersensitivity and cardiovascular diseases (CV...

More on Long-Term Effects of Finasteride on Prostate Cancer Mortality. Reply.

Allopurinol treatment adversely impacts left ventricular mass regression in patients with well-controlled hypertension.

Previous studies have demonstrated that high-dose allopurinol is able to regress left ventricular (LV) mass in cohorts with established cardiovascular disease. The aim of this study was to assess whet...

Clinical Trials [16271 Associated Clinical Trials listed on BioPortfolio]

Study to Evaluate sUA-Lowering Activity, Safety & PK Interaction of Oral BCX4208 & Allopurinol Admin. in Subjects w/Gout

To evaluate safety and efficacy of BCX4208 alone and in combination with allopurinol in subjects with gout.

Cardiovascular Safety of Febuxostat and Allopurinol in Patients With Gout and Cardiovascular Comorbidities

The purpose of this study is to see if subjects with gout who receive febuxostat or allopurinol, once daily (QD), have a higher rate of serious heart and blood vessel complications.

Allopurinol Versus Febuxostat in Subjects Completing the Phase 3 Trials C02-009 or C02-010

The purpose of this study is to determine the long-term safety of febuxostat compared to allopurinol in reducing serum urate levels in subjects with gout.

Intensive Urate Lowering Therapy With Febuxostat in Comparison With Allopurinol on Cardiovascular Risk in Patients With Gout

Comparison of the effects of Febuxostat and Allopurinol on Pulse Wave Velocity (PWV) after 36 weeks of treatment.

Effect of Allopurinol for Hypoxic-ischemic Brain Injury on Neurocognitive Outcome

Neonatal hypoxic-ischemic encephalopathy (HIE) is a major cause of death or long-term disability in infants born at term in the western world, affecting about 1-4 per 1.000 life births and...

Medical and Biotech [MESH] Definitions

A persistent activity-dependent decrease in synaptic efficacy between NEURONS. It typically occurs following repeated low-frequency afferent stimulation, but it can be induced by other methods. Long-term depression appears to play a role in MEMORY.

Persistent detrimental effects from treatment for a condition. Included are effects from surgery such as POSTOPERATIVE COMPLICATIONS, and from DRUG THERAPY, such as CHEMICALLY INDUCED DISORDERS, or other THERAPEUTICS. Failure to attain a desired outcome from treatment for the condition is not considered an adverse effect.

Health insurance to provide full or partial coverage for long-term home care services or for long-term nursing care provided in a residential facility such as a nursing home.

Persons who have experienced prolonged survival of HIV infection. This includes the full spectrum of untreated, HIV-infected long-term asymptomatics to those with AIDS who have survived due to successful treatment.

A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.

Quick Search

DeepDyve research library

Relevant Topics

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Nephrology - kidney function
Nephrology is a specialty of medicine and pediatrics that concerns itself with the study of normal kidney function, kidney problems, the treatment of kidney problems and renal replacement therapy (dialysis and kidney transplantation). Systemic conditions...

Searches Linking to this Article