Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents.

08:00 EDT 16th May 2019 | BioPortfolio

Summary of "Genome-wide DNA methylation profile in the peripheral blood of cocaine and crack dependents."

Cocaine use disorders (CUDs) represent a major public health problem in many countries. To better understand the interaction between the environmental modulations and phenotype, the aim of the present study was to investigate the DNA methylation pattern of CUD patients, who had concomitant cocaine and crack dependence, and healthy controls.


Journal Details

This article was published in the following journal.

Name: Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
ISSN: 1809-452X


DeepDyve research library

PubMed Articles [18906 Associated PubMed Articles listed on BioPortfolio]

Adulterants in crack cocaine in Brazil.

Brazil is the world's biggest consumer of crack cocaine, and dependence is a major public health issue. This is the first study to investigate the prevalence of potentially harmful adulterants present...

Exploring the influence from whole blood DNA extraction methods on Infinium 450K DNA methylation.

Genome-wide DNA methylation studies are becoming increasingly important in unraveling the epigenetic basis of cell biology, aging and human conditions. The aim of the present study was to explore whet...

Genome-wide association study of peripheral blood DNA methylation and conventional mammographic density measures.

Age- and body mass index (BMI)-adjusted mammographic density is one the strongest breast cancer risk factors. DNA methylation is a molecular mechanism that could underlie inter-individual variation in...

DNA methylation among firefighters.

Firefighters are exposed to carcinogens and have elevated cancer rates. We hypothesized that occupational exposures in firefighters would lead to DNA methylation changes associated with activation of ...

DNA methylation from germline cells in veterans with PTSD.

In this study we investigated genome-wide sperm DNA methylation patterns in trauma-exposed Vietnam veterans. At the genome-wide level, we identified 3 CpG sites associated with PTSD in sperm including...

Clinical Trials [11365 Associated Clinical Trials listed on BioPortfolio]

Comprehensive DNA Methylation Profiling in Crohn's Disease

Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed i...

Methylphenidate for Cocaine Dependence

This phase II pilot study aims at evaluating the benefits and the risks of methylphenidate (Concerta®) for the treatment of cocaine/crack dependence in terms of cocaine/crack use reductio...

Infusion Laboratory: Protocol 1 - Selegeline - 2

The purpose of this study is to determine the effects of selegiline on the subjective and physiological effects of cocaine challenge in chronic crack abusers, and to evaluate clinical safe...

A Contribution to the Analysis of the Phenotypic Heterogeneity in Crack/Cocaine Addiction : a Case Control Study

The purpose of this study is to assess the phenotypic candidates symptoms, in patients with crack/cocaine addiction, in terms of clinical comorbidities, dimensions of personality, and neur...

Detection of Colorectal Cancer in Peripheral Blood by Septin 9 DNA Methylation Assay

Epigenomics is developing a colon cancer screening assay based on differential methylation of specific CpG sites for the detection of early stage disease. A genome-wide methylation analysi...

Medical and Biotech [MESH] Definitions

The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.


An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.

Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.

Disorders related or resulting from use of cocaine.

Quick Search

DeepDyve research library

Relevant Topics

Bioinformatics is the application of computer software and hardware to the management of biological data to create useful information. Computers are used to gather, store, analyze and integrate biological and genetic information which can then be applied...

Public Health
Alternative Medicine Cleft Palate Complementary & Alternative Medicine Congenital Diseases Dentistry Ear Nose & Throat Food Safety Geriatrics Healthcare Hearing Medical Devices MRSA Muscular Dyst...

Searches Linking to this Article