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Oral progesterone for the prevention of recurrent preterm birth: systematic review and metaanalysis.

07:00 EST 1st March 2019 | BioPortfolio

Summary of "Oral progesterone for the prevention of recurrent preterm birth: systematic review and metaanalysis."

The purpose of this study was to perform a systematic review and metaanalysis of randomized controlled trials on oral progesterone compared with placebo or other interventions for preterm birth prevention in singleton pregnancies with previous spontaneous preterm birth. The primary outcome was preterm birth at <37 weeks gestation; the secondary outcomes included preterm birth rate at <34 weeks gestation, neonatal morbidity/death, and maternal side-effects.

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Journal Details

This article was published in the following journal.

Name: American journal of obstetrics & gynecology MFM
ISSN: 2589-9333
Pages: 50-62

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Medical and Biotech [MESH] Definitions

Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. The cytosol progesterone-receptor complex then associates with the nucleic acids to initiate protein synthesis. There are two kinds of progesterone receptors, A and B. Both are induced by estrogen and have short half-lives.

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Multi-step systematic review process used for improving safety by investigation of incidents to find what happened, why it happened, and to determine what can be done to prevent it from happening again.

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