Track topics on Twitter Track topics that are important to you
Acylated homoserine lactone (AHL)-mediated quorum sensing (QS) is ecologically important in multi-species systems in laboratory-scale studies; however, little is known about QS in the biofilm formation process in full-scale wastewater treatment plants, which is driven by multiple environmental variables. Here, a model integrated fixed-film-activated sludge system was employed in full-scale municipal wastewater treatment plant to investigate the AHL distribution during the biofilm development process in response to variable environmental factors. The whole biofilm development process can be divided into three phases: initial biofilm attachment process (week 1 to 3), biofilm development and mature phase (week 4 to 6), and biofilm detachment and reformation process (week 7 to 17). N-decanoyl-DL-homoserine lactone (C10-HSL) and N-dodecanoyl-DL-homoserine lactone (C12-HSL) presented high concentrations during the biofilm formation process, which was closely related with the biofilm initial attachment process. The AHL concentration in biofilms was higher than in activated sludge. During the initial attachment process, tryptophan and protein-like substances related to biological substance were strongly positively correlated with all detected AHL concentrations (p < 0.05). Three environmental variables (total nitrogen, pH, and Na) were closely related to AHL distribution in municipal wastewater biofilms. High wastewater pH was found to contribute to a low AHL concentration. AHLs in the biofilm were significantly (p < 0.01) influenced by the concentration of Na, and higher concentrations of Na (10.84-18.58 mg/L) in wastewater treatment plants potentially contribute to the biofilm formation processes. In addition, bacteria with nitrogen removal ability showed QS functionality. The results of this study indicate that AHL-based regulation of tryptophan and protein-like substances related to biological substance production was significantly influenced by the surrounding chemical environment, which has been underestimated in previous studies. AHL-mediated QS potentially suggests a novel solution for the advanced AHL-based regulation of the biofilm development processes.
This article was published in the following journal.
Name: The Science of the total environment
Quorum sensing (QS) has been thoroughly investigated during initial biofilm formation stages, while the role of QS in mature biofilms has received little research attention. This study assessed QS in ...
Signal crosstalk within biological communication networks is common, and such crosstalk can have unexpected consequences for decision making in heterogeneous communities of cells. Here we examined cro...
Pseudomonas aeruginosa is one of the leading causes of opportunistic and hospital-acquired infections worldwide, which is frequently linked with clinical treatment difficulties. Ibuprofen, a widely us...
Quorum sensing is a well-described mechanism of intercellular signalling among bacteria that involves cell-density dependent chemical signal molecules. The concentration of these quorum sensing molecu...
Antimicrobial photodynamic inactivation (APDI) is a new therapeutic modality which needs more precision during application due to the possibility of exposure of bacteria to sub-lethal doses (sAPDI). I...
The purpose of this study is to assess the clinical efficacy of azithromycin, used as a quorum-sensing blocker, when compared to placebo for preventing or delaying the occurrence of pneum...
The purpose of this study is to test the feasibility of the scale-up of sulphadoxine- pyrimethamine (SP) for the preventive treatment of malaria in pregnancy in three Local Government Area...
Introduction: Prematurity has been more frequent in industrialized countries, which is a risk factor for delay in child development. Delays in the development of visual system could be hig...
Pulmonary vein (PV) isolation is very important in atrial fibrillation (AF) catheter ablation. PV reconnection is one of the main reasons in AF recurrence. Contact force-sensing catheter i...
The aim of this single-center prospective randomized controlled trial is to assess the superiority of contact-force-(CF)-sensing-based approach compared to conventional (non-CF-sensing) ap...
A phenomenon where microorganisms communicate and coordinate their behavior by the accumulation of signaling molecules. A reaction occurs when a substance accumulates to a sufficient concentration. This is most commonly seen in bacteria.
Tests designed to assess language behavior and abilities. They include tests of vocabulary, comprehension, grammar and functional use of language, e.g., Development Sentence Scoring, Receptive-Expressive Emergent Language Scale, Parsons Language Sample, Utah Test of Language Development, Michigan Language Inventory and Verbal Language Development Scale, Illinois Test of Psycholinguistic Abilities, Northwestern Syntax Screening Test, Peabody Picture Vocabulary Test, Ammons Full-Range Picture Vocabulary Test, and Assessment of Children's Language Comprehension.
Process whereby a cell, bodily structure, or organism (animal or plant) receives or detects a gravity stimulus. Gravity sensing plays an important role in the directional growth and development of an organism (GRAVITROPISM).
Intracellular signaling peptides and proteins that bind to CALCIUM. They undergo allosteric changes when bound to CALCIUM that affects their interaction with other signal-transducing molecules. They differ from CALCIUM-SENSING RECEPTORS which sense extracellular calcium levels.
A period in the human life in which the development of the hypothalamic-pituitary-gonadal system takes place and reaches full maturity. The onset of synchronized endocrine events in puberty lead to the capacity for reproduction (FERTILITY), development of secondary SEX CHARACTERISTICS, and other changes seen in ADOLESCENT DEVELOPMENT.
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...