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Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice.

07:00 EST 27th February 2019 | BioPortfolio

Summary of "Doxorubicin-induced testicular damage is related to PARP-1 signaling molecules in mice."

Doxorubicin (DOX), is a chemotherapeutic agent, which evokes oxidative stress and cell apoptosis in testicular tissue. It is known that the activation of the nuclear enzyme poly (ADP-ribose) polymerase (PARP), leading to apoptosis induced by DOX. The aim of the present study is to investigate whether PARP pathway has a role in DOX-induced testicular damage and infertility utilizing pharmacological PARP-1 inhibitor, PJ34, and PARP-1 knockout mice model.

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This article was published in the following journal.

Name: Pharmacological reports : PR
ISSN: 1734-1140
Pages: 591-602

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Medical and Biotech [MESH] Definitions

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A family of structurally related proteins that are induced by CYTOKINES and negatively regulate cytokine-mediated SIGNAL TRANSDUCTION PATHWAYS. SOCS proteins contain a central SH2 DOMAIN and a C-terminal region of homology known as the SOCS box.

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