Trilayer scaffold with cardiosphere-derived cells for heart valve tissue engineering.

08:00 EDT 11th June 2019 | BioPortfolio

Summary of "Trilayer scaffold with cardiosphere-derived cells for heart valve tissue engineering."

Natural polymers collagen, glycosaminoglycans, and elastin are promising candidate materials for heart valve tissue engineering scaffolds. This work produced trilayer scaffolds that resembled the layered structures of the extracellular matrices of native heart valves. The scaffolds showed anisotropic bending moduli (in both dry and hydrated statuses) depending on the loading directions (lower in the With Curvature direction than in the Against Curvature direction), which mimicked the characteristic behavior of the native heart valves. The interactions between cardiosphere-derived cells and the scaffolds were characterized by multiphoton microscopy, and relatively similar cell distributions were observed on different layers (a cell density of 3,000-4,000 mm and a migration depth of 0.3-0.4 mm). The trilayer scaffold has represented a forwarding step from the previous studies, in attempting to better replicate a native heart valve structurally, mechanically, and biologically.


Journal Details

This article was published in the following journal.

Name: Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981


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