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Surfaces with a controlled gradient of polymer brushes were fabricated via microfluidically mediated atom-transfer radical polymerization (ATRP). This methodology used a sealed sandwiched setup with a parallel alignment of the initiator-substrate with the metal substrate. A syringe-pump injected small volumes of Cu(i)/L activator/monomer solution directly into the bottom of the setup while ATRP at the frontal initiator-substrate was simultaneously initiated. The trace amount of injection solution locally confined polymerization to occur only on areas in contact with the solution which resulted in the spontaneous formation of gradient structures. A surface-attached polymer gradient was regulated via either the solution injection rate or monomer/catalysis concentration, thereby yielding a controllable gradient with uniformly grafted polymers.
This article was published in the following journal.
Name: Chemical communications (Cambridge, England)
A practical, simple, and efficient copper-catalyzed atom transfer radical addition reaction of alkenes with α-bromoacetonitrile is realized. With this methodology, various γ-bromonitriles and β,γ-...
Here we report a highly selective and ultrasensitive DNA biosensor based on electrochemical atom transfer radical polymerization (ATRP) signal amplification and "Click Chemistry". The DNA biosensor wa...
Over the past decade, the field of polymer-oligonucleotide nanomaterials has flourished because of the development of synthetic techniques, particularly living polymerization technologies, which provi...
Here, the synthesis of a novel poly(pyrrole phenylene) (PpyP) that is both modular in ways of functionalization and soluble in organic solvents is reported, and therefore solution processable. This is...
The Hofmann-Löffler-Freytag (HLF) reaction is a prototypical example of radical-based remote functionalization of unactivated C(sp)-H bond. While 1,5-hydrogen atom transfer (1,5-HAT) of the amidyl ra...
Primary Objectives: 1. To determine the maximum tolerated dose and transduction efficiency of adenoviral mediated wild type p53 gene transfer in premalignancies of the upper aerodi...
OBJECTIVES: Evaluate the efficacy and safety of lipid-mediated transfer of the cystic fibrosis transmembrane conductance regulator gene to nasal epithelium in patients with cystic f...
Polymerization shrinkage remains one of the primary disadvantages of composite resin restorative materials (tooth-colored fillings). To minimize the effects of polymerization shrinkage in ...
Prospective, open, randomized, parallel, two-arm trial to compare the clinical pregnancy rate between most commonly used two embryo transfer techniques: trial followed by transfer techniqu...
The purpose of this study is to compare IVF outcomes between day 3 and day 5 embryo transfer in patients with five or fewer embryos in a fresh embryo transfer in vitro fertilization (IVF) ...
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Sulfur compounds in which the sulfur atom is attached to three organic radicals and an electronegative element or radical.
The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.
Composite materials composed of an ion-leachable glass embedded in a polymeric matrix. They differ from GLASS IONOMER CEMENTS in that partially silanized glass particles are used to provide a direct bond to the resin matrix and the matrix is primarily formed by a light-activated, radical polymerization reaction.
Carbon-containing thiophosphonic acid compounds. Included under this heading are compounds that have carbon bound to either SULFUR atom, PHOSPHOROUS atom, or the OXYGEN atom of the SPO2 core structure.