Family history of pain and risk of musculoskeletal pain in children and adolescents: a systematic review and meta-analysis.

08:00 EDT 8th June 2019 | BioPortfolio

Summary of "Family history of pain and risk of musculoskeletal pain in children and adolescents: a systematic review and meta-analysis."

Emerging evidence suggests that MSK should be viewed from a biopsychosocial perspective and consider the influence of family factors. We conducted a review with meta-analysis to provide summary estimates of effect of family history of pain on childhood MSK pain, and explore whether specific family pain factors influence the strength of the association (PROSPERO CRD42018090130). Included studies reported associations between family history of pain and non-specific MSK pain in children (age <19 years). The outcome of interest was MSK pain in children. We assessed the methodological quality using a modified version of the Quality in Prognosis Studies instrument, and quality of evidence for the main analyses using the GRADE criteria. After screening of 7281 titles; six longitudinal and 23 cross-sectional studies were included. Moderate quality evidence from five longitudinal studies (n=42131) showed that children with family history of MSK pain had 58% increased odds of experiencing MSK pain themselves (OR 1.58, 95% CI 1.20 to 2.09). Moderate quality evidence from 18 cross-sectional studies (n=17274) supported this finding (OR 2.02, 95% 1.69 to 2.42). Subgroup analyses showed that the relationship was robust regardless of whether a child's mother, father or sibling experienced pain. Odds were higher when both parents reported pain compared to one [(mother OR=1.61; father OR=1.59); both parents OR=2.0]. Our findings show moderate quality evidence that children with a family history of pain are at higher risk of experiencing MSK pain. Understanding the mechanism by which this occurs\ would inform prevention and treatment efforts.


Journal Details

This article was published in the following journal.

Name: Pain
ISSN: 1872-6623


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Medical and Biotech [MESH] Definitions

A type of pain that is perceived in an area away from the site where the pain arises, such as facial pain caused by lesion of the VAGUS NERVE, or throat problem generating referred pain in the ear.

Pain in the facial region including orofacial pain and craniofacial pain. Associated conditions include local inflammatory and neoplastic disorders and neuralgic syndromes involving the trigeminal, facial, and glossopharyngeal nerves. Conditions which feature recurrent or persistent facial pain as the primary manifestation of disease are referred to as FACIAL PAIN SYNDROMES.

Dull or sharp aching pain caused by stimulated NOCICEPTORS due to tissue injury, inflammation or diseases. It can be divided into somatic or tissue pain and VISCERAL PAIN.

Acute pain that comes on rapidly despite the use of pain medication.

Pain originating from internal organs (VISCERA) associated with autonomic phenomena (PALLOR; SWEATING; NAUSEA; and VOMITING). It often becomes a REFERRED PAIN.

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