Assessment of long-term risks of secondary cancer in pediatric patients with brain tumor after boron neutron capture therapy.

08:00 EDT 13th June 2019 | BioPortfolio

Summary of "Assessment of long-term risks of secondary cancer in pediatric patients with brain tumor after boron neutron capture therapy."

This study firstly explored the risks of secondary cancer in healthy organs of Chinese pediatric patients with brain tumor after boron neutron capture therapy (BNCT). Three neutron beam irradiation geometries (i.e., RLAT, TOP, PA) were adopted in treating patients with brain tumor under the clinical environment of BNCT. The concerned organs in this study were those with high cancer morbidity in China (e.g., lung, liver, and stomach). The equivalent doses for these organs were calculated using Monte Carlo and anthropomorphic pediatric phantoms with Chinese physiological features. The secondary cancer risk, characterized by the lifetime attributable risk (LAR) factor mentioned in the BEIR VII report, was compared among the three irradiation geometries. Results showed that the LAR was lower with the PA irradiation geometry than with the two other irradiation geometries when the 2 cm-diameter tumor was at a depth of 6 cm at the right brain. Under the PA irradiation geometry, the LAR in the organs increased with increasing tumor volume and depth because of the long irradiation time. As the patients aged from 10 to 15 years, the LAR decreased, which was related to the increased patient height and shortened life expectation. Female patients had a relatively higher secondary cancer risk than male patients in this study, which could be due to the thinner body thickness and the weaker protective effect on the internal organs of the female patients. In conclusion, the risks of secondary cancer in organs were related to irradiation geometries, gender, and age, indicating that secondary cancer risk is a personalized parameter that needs to be evaluated before administering BNCT, especially in patients with large or deep tumors.


Journal Details

This article was published in the following journal.

Name: Journal of radiological protection : official journal of the Society for Radiological Protection
ISSN: 1361-6498


DeepDyve research library

PubMed Articles [53716 Associated PubMed Articles listed on BioPortfolio]

Long-Term Follow-Up in Childhood Cancer Survivors - Position paper 2018 of the working group "long-term follow-up" of the Society of Pediatric Oncology and Hematology (GPOH) on long-term surveillance, long-term follow-up and late effect evaluation in pediatric oncology patients.

Nowadays, childhood cancer patients survive much more often than they did 40 years ago. Therefore, the cure rates rise over 80%. Approximately 33,000 cured childhood cancer patients are documented by ...

The social impact of early psychological maturity in adolescents with cancer.

There is a growing need to assess the long-term quality of life (QOL) of pediatric oncology patients since many children now survive their disease. This paper highlights the subjective perspectives of...

Geriatric Assessment Predicts Hospitalization Frequency and Long-Term Care Use in Older Adult Cancer Survivors.

The association between geriatric assessment (GA)-identified impairments and long-term health care use in older cancer survivors remains unknown. Our objective was to evaluate whether a GA performed a...

The cardiopulmonary bypass and cancer dissemination puzzle1.

Early cancer diagnosis, new therapies that increased survival of patients, besides the increasingly elderly population are some factors would be associated with possible cancer dissemination in patien...

Long-term Effects After Pediatric LASIK for Anisometropic Amblyopia in Two Patients.

To report long-term follow-up of two pediatric patients who underwent laser in situ keratomileusis (LASIK) for myopic anisometropic amblyopia.

Clinical Trials [32967 Associated Clinical Trials listed on BioPortfolio]

Revavtio Special Investigation for Long-term Use in Pediatric Patients

Secondary data collection study: safety and effectiveness of Revatio in pediatric patients under Japanese medical practice

Registry for Analysis of Quality of Life, Normal Organ Toxicity and Survival of Pediatric Patients Treated With Proton Therapy

The study aim of this study is to evaluate the effect of proton therapy on quality of life and long-term normal tissue toxicities of the pediatric cancer patients. Based on these results, ...

Assessment of the Safety and Efficacy of Dupilumab in Children With Asthma (Liberty Asthma Excursion)

Primary Objective: To evaluate the long-term safety and tolerability of dupilumab in pediatric patients with asthma who participated in a previous dupilumab asthma clinical study. ...

Health-Related Outcomes in Patients Who Were Previously Treated for Rhabdomyosarcoma

RATIONALE: Cancer treatment may have risks that affect health outcomes later. It is not yet known what health outcomes may be related to previous treatment for rhabdomyosarcoma. PURPOSE: ...

Getting Long-term Management of Adult Children Cured of Childhood Cancer in Rhône-Alpes

Children cancers are rare and survival rate are around 75%. 1 French adult out of 850 is estimated as a children-cancer-survivor. Chemotherapy, radiotherapy or surgical complications can l...

Medical and Biotech [MESH] Definitions

Registered nurses with graduate degrees in nursing who provide care to pediatric patients who are acutely or critically ill.

A physiochemical process which occurs in a wide range of organisms which unlike BASAL METABOLISM is not required for or essential to short-term survivability but to long-term general well-being of the organism.

Health insurance to provide full or partial coverage for long-term home care services or for long-term nursing care provided in a residential facility such as a nursing home.

Persons who have experienced prolonged survival of HIV infection. This includes the full spectrum of untreated, HIV-infected long-term asymptomatics to those with AIDS who have survived due to successful treatment.

A persistent increase in synaptic efficacy, usually induced by appropriate activation of the same synapses. The phenomenological properties of long-term potentiation suggest that it may be a cellular mechanism of learning and memory.

Quick Search


DeepDyve research library

Relevant Topics

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Searches Linking to this Article