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This study firstly explored the risks of secondary cancer in healthy organs of Chinese pediatric patients with brain tumor after boron neutron capture therapy (BNCT). Three neutron beam irradiation geometries (i.e., RLAT, TOP, PA) were adopted in treating patients with brain tumor under the clinical environment of BNCT. The concerned organs in this study were those with high cancer morbidity in China (e.g., lung, liver, and stomach). The equivalent doses for these organs were calculated using Monte Carlo and anthropomorphic pediatric phantoms with Chinese physiological features. The secondary cancer risk, characterized by the lifetime attributable risk (LAR) factor mentioned in the BEIR VII report, was compared among the three irradiation geometries. Results showed that the LAR was lower with the PA irradiation geometry than with the two other irradiation geometries when the 2 cm-diameter tumor was at a depth of 6 cm at the right brain. Under the PA irradiation geometry, the LAR in the organs increased with increasing tumor volume and depth because of the long irradiation time. As the patients aged from 10 to 15 years, the LAR decreased, which was related to the increased patient height and shortened life expectation. Female patients had a relatively higher secondary cancer risk than male patients in this study, which could be due to the thinner body thickness and the weaker protective effect on the internal organs of the female patients. In conclusion, the risks of secondary cancer in organs were related to irradiation geometries, gender, and age, indicating that secondary cancer risk is a personalized parameter that needs to be evaluated before administering BNCT, especially in patients with large or deep tumors.
This article was published in the following journal.
Name: Journal of radiological protection : official journal of the Society for Radiological Protection
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