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Co-ordination between innate and adaptive immunity is a foremost crucial immunological interactions. The interaction is beneficial for the survival of the host against infectious agent and also detrimental for the pathogen during their future encounter. Major cellular components to bridge the gap of innate and adaptive immune system include B cells, varieties of T cell subsets and their interaction with antigen presenting cells. T cells are the components of immune system which recognise antigen that are specifically presented with the different class of MHC molecules like MHCI and MHCII marking the diversity of exogenous and endogenous nature of antigen. T cells further differentiate in varieties of morphological and immunological forms like CD4+, CD8+ T cells, Th-17, Treg and γδ-T cells based on the nature of antigen, interaction and polarizing factors. Therefore the evolutionary selections of these diversities have a different functional aspect which is not only dependent upon their percentage presence but more promisingly dependent upon their physiological state and local environment. Thus this review is highlighting the major contributions of T cells subsets using an infectious disease model of visceral leishmaniasis and also helpful in explaining the reason for the non-responsiveness of the T cells subsets during the onset and progression of infection.
This article was published in the following journal.
Name: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
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A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). The sandfly genera Phlebotomus and Lutzomyia are the vectors.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). Human infections are confined almost entirely to children. This parasite is commonly seen in dogs, other Canidae, and porcupines with humans considered only an accidental host. Transmission is by Phlebotomus sandflies.
A form of LEISHMANIASIS, CUTANEOUS caused by Leishmania aethiopica in Ethiopia and Kenya, L. pifanoi in Venezuela, L. braziliensis in South America, and L. mexicana in Central America. This disease is characterized by massive dissemination of skin lesions without visceral involvement.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals including rodents. The Leishmania mexicana complex causes both cutaneous (LEISHMANIASIS, CUTANEOUS) and diffuse cutaneous leishmaniasis (LEISHMANIASIS, DIFFUSE CUTANEOUS) and includes the subspecies amazonensis, garnhami, mexicana, pifanoi, and venezuelensis. L. m. mexicana causes chiclero ulcer, a form of cutaneous leishmaniasis (LEISHMANIASIS, CUTANEOUS) in the New World. The sandfly, Lutzomyia, appears to be the vector.
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Allergies Automimmune Disease Human Papillomavirus (HPV) Immunology Vaccine Immunology is the study of immunity and the defence mechanisms of the body. A greater understanding of immunology is needed to develop vaccines, understand ...