Potent and durable antibacterial activity of ZnO-dotted nanohybrids hydrothermally derived from ZnAl-layered double hydroxides.

08:00 EDT 7th June 2019 | BioPortfolio

Summary of "Potent and durable antibacterial activity of ZnO-dotted nanohybrids hydrothermally derived from ZnAl-layered double hydroxides."

The search for effective alternatives to traditional antibiotics to avoid antibiotic resistant bacteria is growing worldwide. ZnO nanoparticles are found to effectively inhibit growth and proliferation of bacteria, and ZnO-based layered double hydroxides (ZnO-based LDHs) have been intensively investigated for this purpose. However, the nanocomposites are made in a multi-step preparation process with severe agglomeration and limited bactericidal ability. In this research, ZnO-dotted nanohybrids using ZnAl-LDHs as precursors (ZnO-dotted LDHs or ZnO/LDHs) were synthesized under facile hydrothermal conditions. An understanding of the transformation of the LDH precursors to the ZnO/LDHs was conducted with TEM/HRTEM/XRD/FTIR. ZnO/LDHs can be transformed from ZnAl-LDHs, with more ZnO nanodots generated upon heating at 150 and 200 °C for 2 h (ZnAl-150, ZnAl-200). ZnAl-200 nanohybrids showed potent antibacterial activity towards Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) at 100-300 μg/mL for 4 days. Antibacterial activity of ZnAl-200 may be attributed to the synergistic effects (ROS, leached Zn and physical interaction). This research thus suggests a potential economic approach to prepare ZnO/LDH nanocomposites for avoiding the antibiotic resistant bacteria in environmental engineering or clinic fields.


Journal Details

This article was published in the following journal.

Name: Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Pages: 585-592


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