A Portable Device for Rapid Detection of Human Serum Albumin using an immunoglobulin-coating-based Magnetoelastic Biosensor.

08:00 EDT 1st June 2019 | BioPortfolio

Summary of "A Portable Device for Rapid Detection of Human Serum Albumin using an immunoglobulin-coating-based Magnetoelastic Biosensor."

Abnormal protein concentration levels in human body fluids, such as urine, serum etc., are considered to associate with disease states, providing essential information for the pre-clinical diagnosis. This paper presents a wireless immunoglobulin-coated magnetoelastic (ME) biosensor for fast, cost-effective detections of human serum albumin (HSA) with small sample volumes at a microliter scale. This is the first portable resonant sensor based on magnetostrictive effect that can monitor different molecular states of HSA. Anti-HSA Immunoglobulin G (IgG) was immobilized on the surface of the ME sensor to selectively capture HSA. The rapid conjugation between the antibody and antigen changed the sensor surface states and thus induced resonance frequency shifts (RFS), which were monitored in real time for the qualitative and quantitative analysis of HSA. This paper brings forward a System on Chip (SoC)-based system architecture to realize the function of RFS sampling. The performance of the portable device was validated to be comparable to that of the Vector Network Analyzer (VNA) AV3620 using different concentrations of HSA solution. The RFS were linearly proportional to the HSA concentrations in the range from 0.1 to 100 μg/mL with a linearity up to 0.998, a sensitivity of 8.70 Hz/μg.mL-1 and a detection limit of 0.039 μg/mL, indicating good feasibility of this method. Meanwhile, the response of this portable ME biosensor was quick and specific to HSA targets. This ME biosensor shows high potential to be used in diagnosing abnormal HSA.


Journal Details

This article was published in the following journal.

Name: Biosensors & bioelectronics
ISSN: 1873-4235
Pages: 111399


DeepDyve research library

PubMed Articles [23595 Associated PubMed Articles listed on BioPortfolio]

Nanostructured Au-Pt hybrid disk electrodes for enhanced parathyroid hormone detection in human serum.

Most clinical tests for biomarker detection require the support of a laboratory, and the results are usually slow, less sensitive, and lack the possibility for Point-of-Care (PoC) testing. Further, wi...

A fully portable microchip real-time PCR for rapid detection of pathogen.

Point-of-care detection for pathogen is of critical need for wide epidemic warning and medical diagnosis. In this work, we designed and developed a fully portable and integrated microchip based real-t...

A portable nucleic acid detection system using natural convection combined with a smartphone.

The development of portable nucleic acid diagnostic devices has the potential to expand the availability of molecular diagnostics into low-resource settings. One of the promising solutions for rapid a...

Immediate hypersensitivity reaction to human serum albumin in a child undergoing plasmapheresis.

Human serum albumin (HSA) is a commonly used colloid for volume expansion and albumin replacement and during plasmapheresis. Colloids are an uncommon cause of anaphylaxis, and cases of hypersensitivit...

Rapid and in-situ detection of fecal indicator bacteria in water using simple DNA extraction and portable loop-mediated isothermal amplification (LAMP) PCR methods.

Contamination of water by fecal matter and potential human enteric pathogens is a serious health concern. Microbiological water quality has been assessed by conventional culture-based methods of fecal...

Clinical Trials [12874 Associated Clinical Trials listed on BioPortfolio]

Voluven® in Paediatric Patients

This study will compare the clinical efficacy and safety of Voluven® and Human Albumin during elective open-heart surgery in pediatric patients.

Optimization of Therapeutic Human Serum Albumin Infusion in Selected Critically Ill Patients

Primary purpose : mortality at Day 28 Secondary purposes : - Daily SOFA (Sequential Organ Failure Assessment) score lessening within Intensive Care Unit (ICU) - D...

Study of Recombinant Human Serum Albumin/Interferon alpha2b Fusion Protein in Hepatitis B Patient

The purpose of this study is to evaluate the dosages of recombinant human serum albumin/interferon alpha2b fusion protein injection on HBV subjects. The secondary purposes is to get the PK...

Study of Recombinant Human Serum Albumin/Interferon alpha2b Fusion Protein in Chinese Healthy Volunteers

The purpose of this study is to evaluate the dosages of recombinant human serum albumin/interferon alpha2b fusion protein injection in healthy subjects.

Albumin for Hepatocellular Carcinoma

The rate of liver cirrhosis is about 40% to 75% among patients with hepatocellular carcinoma (HCC). Therefore, many patients with HCC were with low serum albumin before and after (especial...

Medical and Biotech [MESH] Definitions

Serum albumin from humans. It is an essential carrier of both endogenous substances, such as fatty acids and BILIRUBIN, and of XENOBITOICS in the blood.

A condition in which albumin level in blood (SERUM ALBUMIN) is below the normal range. Hypoalbuminemia may be due to decreased hepatic albumin synthesis, increased albumin catabolism, altered albumin distribution, or albumin loss through the urine (ALBUMINURIA).

Normal human serum albumin mildly iodinated with radioactive iodine (131-I) which has a half-life of 8 days, and emits beta and gamma rays. It is used as a diagnostic aid in blood volume determination. (from Merck Index, 11th ed)

All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)

Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)

Quick Search


DeepDyve research library

Relevant Topics

An antibody is a protein produced by the body's immune system when it detects harmful substances, called antigens. Examples of antigens include microorganisms (such as bacteria, fungi, parasites, and viruses) and chemicals. Antibodies may be produc...

Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...

Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...

Searches Linking to this Article