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Mode volume overlap factor is one of the parameters determining the sensitivity of a sensor. In past decades, many approaches have been proposed to increase the mode volume overlap. As the increased mode volume overlap factor results in reduced mode confinement, the maximum value is ultimately determined by the micro- and nano-structure of the refractive index distribution of the sensing devices. Due to the asymmetric index profile along the vertical direction on silicon-on-insulator platform, further increasing the sensitivity of subwavelength grating metamaterial (SGM) waveguide based sensors is challenging. In this paper, we propose and demonstrate pedestaled SGM which reduces the asymmetricity and thus allows further increasing the interaction between optical field and analytes. The pedestal structure can be readily formed by a controlled undercut etching. Both theoretical analysis and experimental demonstration show a significant improvement of sensitivity. The bulk sensitivity and surface sensitivity are improved by 28.8% and 1000 times, respectively. The detection of streptavidin at a low concentration of 0.1 ng/mL (∼1.67 pM) is also demonstrated through real-time monitoring of the resonance shift. A ∼400 fM streptavidin limit of detection is expected under 0.01nm resolution spectra analyzer based on the real-time measurement of streptavidin detection results with two-site binding model fitting.
This article was published in the following journal.
Name: Biosensors & bioelectronics
We present a GeSbTe (GST)-integrated ring resonator with the tuning enabled by an all-optical phase change of GST using a sequence of optical pulses. The tuning is non-volatile and repeatable, with no...
This study proposes a Fibonacci subwavelength circular grating (FiSCG) arranged with Au concentric annuli. The numerical results show that, when illuminated by radially polarized light with a waveleng...
We propose an integrated holographic waveguide display system. An infrared volume holographic grating (IVHG) and a visible light grating are recorded on the same waveguide to achieve the purpose of a ...
We demonstrate an all-fiber single-longitudinal-mode (SLM) narrow-linewidth ring laser stabilized by a microsphere resonator and fiber Bragg gratings (FBGs) with a large continuous wavelength tuning r...
A subwavelength metal grating for generating azimuthally polarized beams was designed. The grating material was determined by calculating the total thermal conductivity coefficient. A modified particl...
An extension study for subjects with prior participation in previous resonator studies using low level magnetic fields to treat some of the symptoms of idiopathic Parkinson's Disease.
The purpose of this study is to see if a device called the Resonator can help to improve aspects of health and quality of life that are relevant to patients with Parkinson's disease.
The purpose of this study is to see if using a device called the Resonator, that puts out a very low electromagnetic field, effects blood glucose and A1c levels in people with Type 2 Diabe...
Objectives. To develop a new treatment for astigmatism-related amblyopia using a perceptual learning approach. Hypothesis to be tested. Our proposed experiments are designed to investigat...
The purpose of the study is to assess the performance and safe use of the vaginal ring applicator as an optional aid for insertion of a placebo vaginal ring into the vagina in healthy wome...
A group of two-ring heterocyclic compounds consisting of a benzene ring fused to a diazepine ring.
Compounds based on a seven-membered ring fused to a five-membered ring. Heat can rearrange them to NAPHTHALENES which have two fused six-membered rings. They are similar to guaiazulenes which are SESQUITERPENES with a six-membered ring fused to a five-membered ring.
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
Compounds that contain a BENZENE ring fused to a furan ring.
Compounds with a benzene ring fused to a thiazole ring.