Clinical impacts of using serum IL-6 level as an indicator of cytokine release syndrome after HLA-haploidentical transplantation with post-transplantation cyclophosphamide.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "Clinical impacts of using serum IL-6 level as an indicator of cytokine release syndrome after HLA-haploidentical transplantation with post-transplantation cyclophosphamide."

HLA-haploidentical allogeneic hematopoietic cell transplantation using post-transplantation cyclophosphamide (PT/Cy-haplo) is widely used due to advantages such as low procedural costs, high probability of finding donors, and donor availability at short notice. Cytokine release syndrome (CRS), resulting from bi-directional alloreaction between host and donor, occurs very frequently in PT/Cy-haplo, especially when peripheral blood is used. Severe and life-threatening instances of CRS have been reported. However, the clinical significance of CRS remains unclear. Serum IL-6 levels were used as a surrogate marker of CRS to evaluate the impact of outcomes in 65 consecutive patients receiving PT/Cy-haplo at our institute. Our results indicated that active disease status, high hematopoietic cell transplantation-specific comorbidity index (HCT-CI) scores and very severe CRS were significantly related to peak serum IL-6 levels. High peak levels of serum IL-6 and severe CRS were significantly associated with the development of grade III or IV acute graft-versus-host disease (GVHD). High peak levels of serum IL-6 was a significant risk factor for poor 3 yr-overall survival. Our results suggest that even transient CRS following PT/Cy-haplo may contribute to poor survival due to an increase in severe acute GVHD.


Journal Details

This article was published in the following journal.

Name: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536


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