Advertisement

Topics

Clinical impacts of using serum IL-6 level as an indicator of cytokine release syndrome after HLA-haploidentical transplantation with post-transplantation cyclophosphamide.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "Clinical impacts of using serum IL-6 level as an indicator of cytokine release syndrome after HLA-haploidentical transplantation with post-transplantation cyclophosphamide."

HLA-haploidentical allogeneic hematopoietic cell transplantation using post-transplantation cyclophosphamide (PT/Cy-haplo) is widely used due to advantages such as low procedural costs, high probability of finding donors, and donor availability at short notice. Cytokine release syndrome (CRS), resulting from bi-directional alloreaction between host and donor, occurs very frequently in PT/Cy-haplo, especially when peripheral blood is used. Severe and life-threatening instances of CRS have been reported. However, the clinical significance of CRS remains unclear. Serum IL-6 levels were used as a surrogate marker of CRS to evaluate the impact of outcomes in 65 consecutive patients receiving PT/Cy-haplo at our institute. Our results indicated that active disease status, high hematopoietic cell transplantation-specific comorbidity index (HCT-CI) scores and very severe CRS were significantly related to peak serum IL-6 levels. High peak levels of serum IL-6 and severe CRS were significantly associated with the development of grade III or IV acute graft-versus-host disease (GVHD). High peak levels of serum IL-6 was a significant risk factor for poor 3 yr-overall survival. Our results suggest that even transient CRS following PT/Cy-haplo may contribute to poor survival due to an increase in severe acute GVHD.

Affiliation

Journal Details

This article was published in the following journal.

Name: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Pages:

Links

DeepDyve research library

PubMed Articles [34680 Associated PubMed Articles listed on BioPortfolio]

The dynamics of human total and activated anti-mullerian hormone serum levels in different life periods.

Here, changes in the serum level of total anti-mullerian hormone (AMH) and its activated form in children of both sexes and women with different reproductive status are investigated. This TGFβ superf...

IL-17 and colorectal cancer: From carcinogenesis to treatment.

Colorectal cancer (CRC) is one of the most common types of cancer in the world. Several factors contribute to the development of this cancer. Tumor formation in colon triggers immune responses such as...

Cytokine profile of macrophage activation syndrome associated with Kawasaki disease.

The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disea...

Serum level of macrophage migration inhibitory factor predicts severity and prognosis in patients with ischemic stroke.

To evaluate whether the macrophage migration inhibitory factor (MIF) level in serum of ischemic stroke patients was associated with their clinical severity and early outcome.

Changes of cytokine profile in the blood of pregnant women with anemia.

The aim of this study was to investigate the level of serum cytokines in different periods of pregnancy associated with anemia. 85 pregnant patients with anemia were examined. 46 of them were in their...

Clinical Trials [9352 Associated Clinical Trials listed on BioPortfolio]

Tocilizumab for Cytokine Release Syndrome Prophylaxis in Haploidentical Transplantation

Tocilizumab will be administered prior to transplantation in order to prevent the onset of cytokine release syndrome and its complications associated to peripheral blood haploidentical hem...

The Iron Content of Ferritin in Serum and Urine of Children With High Serum Ferritin Levels

A serum ferritin level can reflect the total body iron content, thus a very low serum ferritin is commonly used as an indicator of iron deficiency and a very high serum ferritin is commonl...

Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients

Cerebral aneurysm surgery has significant mortality and morbidity rate. Inflammation plays a key role in the pathogenesis of intracranial aneurysms, their rupture, subarachnoid haemorrhage...

Multiple Sclerosis

A significant variation in the serum concentration of the circulating cytokine TWEAK is associated with the onset of an inflammatory attack of MS. Study the concentration variations of the...

Identifying Serum Cytokine Profiles of Distinct Inflammatory Phenotypes in Severe Asthma

The aim of this study is to determine and compare serum cytokine levels of six different severe asthma inflammatory phenotypes differentiated by their atopy, peripheral eosinophilia and/or...

Medical and Biotech [MESH] Definitions

An indicator and reagent. It has been used in serum albumin determinations and as a pH indicator.

Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.

Works about randomized clinical trials that compare interventions in clinical settings and which look at a range of effectiveness outcomes and impacts.

Amyloid P component is a small, non-fibrillar glycoprotein found in normal serum and in all amyloid deposits. It has a pentagonal (pentaxin) structure. It is an acute phase protein, modulates immunologic responses, inhibits ELASTASE, and has been suggested as an indicator of LIVER DISEASE.

An indicator and reagent. It has been used for several purposes including the determination of serum albumin concentrations

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Cytokine
Cytokines include chemokines, lymphokines, and monokines. Cells of the immune system communicate with one another by releasing and responding to chemical messengers called cytokines. These proteins are secreted by immune cells and act on other cells to...

Transplantation
Organ transplantation is the moving of an organ from one body to another or from a donor site to another location on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative ...


Searches Linking to this Article