Advertisement

Topics

Alteration of the intestinal microbiota by broad-spectrum antibiotic use correlates with the occurrence of intestinal graft-versus-host disease.

08:00 EDT 10th June 2019 | BioPortfolio

Summary of "Alteration of the intestinal microbiota by broad-spectrum antibiotic use correlates with the occurrence of intestinal graft-versus-host disease."

Patients undergoing hematopoietic stem cell transplantation (HSCT) frequently receive empiric antibiotics during the neutropenic period before engraftment. Several recent studies have shown that anaerobes in the intestine are important mediators of intestinal homeostasis and that commensal bacteria can be potent modulators of the severity of acute graft-versus-host disease (aGvHD). However, the relationships between the type of antibiotic used during the neutropenic period, changes in the intestinal microbiota, and subsequent occurrence of aGvHD are not clear. A total of 211 patients receiving HSCT were stratified into three groups: patients who were not treated with any antibiotics during the neutropenic period (group 1, n = 43); patients treated with cefepime only (group 2, n = 87); and patients treated with carbapenem antibiotics, defined as meropenem or prepenem with/without prior cefepime therapy (group 3, n = 81). Intestinal microbiota analyses were performed on pre- and post-HSCT stool samples and immunophenotypic analyses were performed on pre- and post-HSCT peripheral blood samples. Among the 211 patients, 95 patients (45%) developed aGvHD (≥grade 2), including 54 with intestinal GvHD. Patients in group 3 had a higher incidence of intestinal aGvHD (32.1%) than patients in group 1 (11.6%) and group 2 (26.4%), respectively (P = 0.044). After adjusting for potentially significant variables identified by univariate analysis, multivariate analyses revealed that broad-spectrum antibiotic use during the neutropenic period was associated with the occurrence of intestinal GvHD [HR (95% CI) 3.25 (1.13-9.34), P=0.029]. Accordingly, loss of bacterial diversity in terms of alterations in intestinal microbiota after HSCT was observed in patients who received broad-spectrum antibiotics. Moreover, alterations in the frequencies of several intestinal bacteria phyla were associated with the occurrence of intestinal GvHD. When we evaluated circulating immune cell subsets according to type of antibiotic used during the neutropenic period, delayed recovery of myeloid-derived suppressor cells was observed in the broad-spectrum antibiotic group. Our data indicate that use of broad-spectrum antibiotics during the neutropenic period is associated with a higher incidence of intestinal GvHD via loss of microbiome diversity. Further studies are needed to determine whether maintaining bacterial diversity prevents aGvHD development.

Affiliation

Journal Details

This article was published in the following journal.

Name: Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
ISSN: 1523-6536
Pages:

Links

DeepDyve research library

PubMed Articles [10473 Associated PubMed Articles listed on BioPortfolio]

Broad-spectrum antibiotic prescriptions are unevenly discontinued throughout the week.

To investigate prescribing patterns of in-hospital broad-spectrum antibiotics (anti-meticillin-resistant Staphylococcus aureus drugs, carbapenems, and piperacillin/tazobactam), we analysed data of the...

Effect of broad-spectrum antibiotics on bacterial translocation in burned or septic rats.

Antibiotics are frequently used to treat critically ill patients, and its use is often accompanied by intestinal dysbiosis that might further lead to bacterial translocation (BT). Nevertheless, studie...

Targets for optimizing oral antibiotic prescriptions for pediatric outpatients in Japan.

In Japan, 92.6% of antibiotics consumed are oral agents, most of which are for outpatients. A significant proportion is known to be dispensed for children; however, the specific pattern of antibiotic ...

Effects of hexavalent chromium on intestinal histology and microbiota in Bufo gargarizans tadpoles.

Chromium is detrimental heavy metal pollutants and can enter and affect aquatic organisms. In our experiment, B. gargarizans embryos were chronically exposed in different concentrations of Cr (VI) (0...

Antibiotics exacerbated colitis by affecting the microbiota, Treg cells and SCFAs in IL10-deficient mice.

Many studies have shown that antibiotic therapy can attenuate colitis in IL10-deficient (IL10) mice. However, these results have indicated that antibiotics were more successful in preventing, rather t...

Clinical Trials [4718 Associated Clinical Trials listed on BioPortfolio]

Intestinal Microbiota Composition After Antibiotic Treatment in Early Life

In this prospective observational cohort study the potential clinical consequences of antibiotic use in early life and perturbations in the gastrointestinal microbiota composition due to t...

Intestinal Microbiota Survey of Polycystic Ovary Syndrome

Polycystic Ovary Syndrome is kind of disease with unclear etiology. Recent studies on intestinal microbiota have raised the possibility that dysbiosis of intestinal microbiota maybe a nove...

Study of the Interactions Between Dientamoba Fragilis and the Gut Microbiota

D.fragilis is an intestinal protozoon that feeds by phagocytosis of intestinal bacteria. The study aim to determine if the carriage of the intestinal parasite D.fragilis is associated to c...

IMT for Primary Clostridium Difficile Infection

This is a randomized controlled trial to compare the effect of a 10-day course of per oral Metronidazole versus a one-time rectal instillation of an anaerobically cultivated human intestin...

Reducing Antibiotic Prescribing in Family Practice

Antibiotic prescribing for childhood acute respiratory tract infections (ARTIs), including acute otitis media (AOM), pharyngitis, sinusitis, bronchitis, and upper respiratory infection (UR...

Medical and Biotech [MESH] Definitions

A broad-spectrum spectrum antineoplastic antibiotic isolated from Streptomyces refuineus var. thermotolerans. It has low toxicity, some activity against Trichomonas and Endamoeba, and inhibits RNA and DNA synthesis. It binds irreversibly to DNA.

An antibiotic first isolated from cultures of Streptomyces venequelae in 1947 but now produced synthetically. It has a relatively simple structure and was the first broad-spectrum antibiotic to be discovered. It acts by interfering with bacterial protein synthesis and is mainly bacteriostatic. (From Martindale, The Extra Pharmacopoeia, 29th ed, p106)

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

Semisynthetic, broad-spectrum antibiotic derivative of CEPHALEXIN.

Orally active semisynthetic cephalosporin antibiotic with broad-spectrum activity.

Advertisement
Quick Search
Advertisement
Advertisement

 


DeepDyve research library

Relevant Topics

Stem Cells
Track and monitor developments in stem cell research and commercial development.  Follow the tabs above to read the latest global news, research, clinical trials on stem cells and follow companies active in the stem cell industry.  BioPort...

Transplantation
Organ transplantation is the moving of an organ from one body to another or from a donor site to another location on the patient's own body, for the purpose of replacing the recipient's damaged or absent organ. The emerging field of regenerative ...


Searches Linking to this Article